Evidence map›Paper›PMID 40448344›Full record

ReviewCancer medicine2025

Recent Findings in N6-Methyladenosine Modification and Significance in Pancreatic Cancer.

Tomoaki Hara, Sikun Meng, Yasuko Arao, Yoshiko Saito, Kana Inoue, Sarah Rennie, Ken Ofusa, Toru Kitagawa, Hideshi Ishii

Abstract readReview
In one paragraph

Review in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. MondoA mediates transcriptional coordination between the MYC network and the integrated stress response in pancreatic cancer.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Review
  4. Inhibition ofACS omega · 2025
    Article
  5. Article
  6. Inhibition ofbioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tomoaki HaraDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Osaka, Japan.
Sikun MengDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Osaka, Japan.
Yasuko AraoDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Osaka, Japan.
Yoshiko SaitoDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Osaka, Japan.
Kana InoueDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Osaka, Japan.
Sarah RennieSection for Computational and RNA Biology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.
Ken OfusaDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Osaka, Japan.
Toru KitagawaDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Osaka, Japan.
Hideshi IshiiDepartment of Medical Data Science, Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Osaka, Japan.ORCID https://orcid.org/0000-0002-0632-6517

Funding

Ministry of Education, Culture, Sports, Science and Technology 16H06279 [PAGS]Ministry of Education, Culture, Sports, Science and Technology 17cm0106414h0002Ministry of Education, Culture, Sports, Science and Technology 19K22658Ministry of Education, Culture, Sports, Science and Technology 20H00541Ministry of Education, Culture, Sports, Science and Technology 21K19526Ministry of Education, Culture, Sports, Science and Technology 22H03146Ministry of Education, Culture, Sports, Science and Technology 22K19559Ministry of Education, Culture, Sports, Science and Technology 23K18313Ministry of Education, Culture, Sports, Science and Technology JP21lm0203007Ministry of Education, Culture, Sports, Science and Technology JP23ym0126809Mitsubishi Foundation 2021-48Takahashi Industrial and Economic Research Foundation 2023
6 · The paper itself

Abstract

backgroundRNA modifications are widely detected in cells and are involved in RNA structural stabilization and regulation of gene expression. In cancer cells, RNA modifications are altered, resulting in abnormal expression of numerous genes and promoting cancer growth. N1-methyladenosine (m

aimIn this review, the function of m METHODOLOGY: We summarize recent reports on m

resultsRNA modifications are written to the RNA by the writer, and the reader binds to the RNA modification, causing gene expression to increase or decrease. Gene expression is also regulated by the removal of RNA modifications by the eraser. Moreover, our recent investigation into m

conclusionThese findings suggest that further exploration of RNA modification functions may facilitate the identification of novel biomarker and therapeutic target molecules for pancreatic cancer.

Indexed as

AdenosinePancreatic NeoplasmsRNA Processing, Post-TranscriptionalAnimalsBiomarkers, TumorGene Expression Regulation, NeoplasticHumansMethyltransferasesRNA-Binding ProteinsAdenosineBiomarkers, TumorMethyltransferasesMETTL14 protein, humanN-methyladenosineRNA-Binding Proteinsm6AMETTL3pancreatic cancerRNA modificationsTCEAL8

Identifiers

PMID40448344
PMCPMC12125277

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.