Evidence map›Paper›PMID 40448342›Full record

ReviewJournal of intensive care medicine2026

Acute Febrile Encephalopathy with Rigidity.

Dearbhla M Kelly, Eoin M Kelleher

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of intensive care medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Dearbhla M KellyOxford Critical Care, John Radcliffe Hospital, University of Oxford, Oxford, UK.ORCID 0000-0002-4318-2030
Eoin M KelleherNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID 0000-0003-2025-5556

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Febrile encephalopathy with rigidity can be the presenting feature of several life-threatening neurological emergencies such as neuroleptic malignant syndrome (NMS) and serotonin syndrome. Although the pathogenesis of these conditions is poorly understood, we review advances in our understanding of underlying genetic and other biological mechanisms. We also discuss the complex and expanding differential diagnoses which include other drug-induced hyperpyrexia or rigidity syndromes (eg malignant hyperthermia, parkinsonism-hyperpyrexia syndrome, malignant catatonia) as well as autoimmune syndromes. Finally, we consider potential predictive and preventative approaches along with best practice management strategies.

Indexed as

Brain DiseasesFeverMuscle RigidityNeuroleptic Malignant SyndromeDiagnosis, DifferentialHumansMalignant HyperthermiaSerotonin Syndromehyperpyrexiamalignant hyperthermianeuroleptic malignant syndromeparkinsonism-hyperpyrexia syndromerigidityserotonin syndrome

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.