SynthesisEuropean journal of medical research2025
Risk factors and mortality of postoperative acute kidney injury (AKI) in newborns across geographical regions, surgical type, and national economic levels: a systematic review and meta-analysis.
Synthesis in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pediatric Postoperative Acute Kidney Injury After Noncardiac Surgery: A Systematic Review and Meta-Analysis.Paediatric anaesthesia · 2026Pooled it
- Research progress on biomarkers for acute kidney injury in children.Pediatric nephrology (Berlin, Germany) · 2026Review
- Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundIt is noted that postoperative acute kidney injury (AKI) in neonates is known to be associated with adverse outcomes, yet its incidence and risk factors remain incompletely elucidated. The current study aims to improve the understanding of postoperative AKI in neonates by systematically evaluating its incidence, diagnostic criteria, risk factors, and clinical outcomes, with particular attention to variations across geographic regions, surgical types, the span of time, and national economic statuses.
methodsA comprehensive search of Pubmed, Embase, OVID, Web of Science (WOS), Medline, and Cochrane Controlled Register of Trials (CENTRAL) was conducted from inception to 30 September 2024. Studies meeting all the following inclusion criteria were enrolled: 1) Population: neonates aged ≤ 30 days; 2) Disease: postoperative AKI diagnosed per KDIGO, pRIFLE, AKIN, nKDIGO, or others; 3) Study design: prospective/retrospective cohort studies or case-control studies; 4) Reporting data on postoperative incidence of AKI. The pooled proportion (along with 95% confidence intervals [CI]) of postoperative AKI was calculated. We also calculated pooled odds ratios (95% CI) for all-cause mortality in neonates with postoperative AKI when compared with those without AKI.
resultsA total of 69 studies (10,519 cases) were included in the meta-analysis. The pooled incidence of postoperative AKI in neonates was 37% (95%CI 32-42, I
conclusionsPostoperative AKI affects one-third of neonates, and AKI-associated mortality remains high. Future efforts should focus on developing earlier and more sensitive detection methods. SYSTEMATIC REVIEW REGISTRATION NUMBER: This meta-analysis was registered on https://www.crd.york.ac.uk/prospero/ with the registration number CRD 42024602820 on October 29, 2024.
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