ArticleAIDS research and therapy2025
Determinants of HIV infection among infants born to HIV positive women receiving option B + prevention of mother to child transmission of HIV in Tigray, north Ethiopia: a case control study.
Article in AIDS research and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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5 authors.
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Abstract
backgroundThe option B
methodsUnmatched case-control study was conducted in Tigray region from October 2023 to April 2024. A total of 43 cases and 129 controls were selected using simple random sampling technique. Multivariable logistic regression analysis was fitted to identify the factors associated with mother to child transmission of human immunodeficiency virus at P < 0.05. Multicolinearity was checked among predictor variables using Variance Inflation Factor and Tolerance test. Furthermore, the goodness of fit of the logistic model was tested using Hosmer-Lemshow test.
resultsThis study showed that rural residence (Adjusted Odds ratio: 33.3, 95% CI: 1.02-87.05), World Health Organization disease stage III (Adjusted Odds ratio: 57.4, CI: 9.25- 297.54) and IV (Adjusted Odds ratio: 78.9, CI: 12.64-345.62) during initiation of antiretroviral therapy and a child with mouth ulcer during exclusive breastfeeding (Adjusted Odds ratio: 65, IC: 6.39-456.23) were the factors significantly associated with mother to child transmission of human immunodeficiency virus. Besides, mothers' educational status (Adjusted Odds ratio: 0.2, CI: 0.04, 0.35), late time of antiretroviral therapy initiation after human immunodeficiency virus diagnosis (Adjusted Odds ratio: 0.14, CI: 0.02-0.18) and absence of human immunodeficiency virus exposed infant follow up visit (Adjusted Odds ratio: 0.04, IC: 0.005-0.09) had significant association with the mother to child transmission of human immunodeficiency virus.
conclusionThe determinant factors significantly associated with mother to child transmission of human immunodeficiency virus were identified. Health care providers should strengthen option B + prevention mother to child transmission of human immunodeficiency virus services to reduce the mother to child transmission of human immunodeficiency virus.
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