Evidence map›Paper›PMID 40448152›Full record

ReviewJournal of nanobiotechnology2025

Advanced oral drug delivery systems for gastrointestinal targeted delivery: the design principles and foundations.

Yafei Zhang, Yiran Wang, Yao Lu, Heng Quan, Yuqi Wang, Sijia Song, Huiyuan Guo

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yafei ZhangCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Yiran WangCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Yao LuCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Heng QuanKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100089, China.
Yuqi WangCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Sijia SongKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100089, China.
Huiyuan GuoCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China. guohuiyuan@cau.edu.cn.

Funding

Chinese Universities Scientific Fund 2024TC177National Key Research and Development Program of China 2023YFF1104501the 111 project from the Education Ministry of China No. B18053the Beijing Outstanding Young Scientist Program JWZQ2024101019
6 · The paper itself

Abstract

Oral administration has long been considered the most convenient method of drug delivery, requiring minimal expertise and invasiveness. Unlike injections, it avoids discomfort, wound infections, and complications, leading to higher patient compliance. However, the effectiveness of oral delivery is often hindered by the harsh biological barriers of the gastrointestinal tract, which limit the bioaccessibility and bioavailability of drugs. The development of oral drug delivery systems (ODDSs) represents a critical area for the advancement of pharmacotherapy. This review highlights the characteristics and precise targeting mechanisms of ODDSs. It first examines the unique properties of each gastrointestinal compartment, including the stomach, small intestine, intestinal mucus, intestinal epithelial barrier, and colon. Based on these features, it outlines the targeting strategies and design principles for ODDSs aimed at overcoming gastrointestinal barriers to enhance disease treatment. Lastly, the review discusses the challenges and potential future directions for ODDS development, emphasizing their importance for advancing drug delivery technologies and accelerating their future growth.

Indexed as

Drug Delivery SystemsGastrointestinal TractAdministration, OralAnimalsBiological AvailabilityHumansBiological barrierCarrierGastrointestinal tractInflammatory bowel diseaseTargeting

Identifiers

PMID40448152
PMCPMC12124048

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.