ArticleBiological research2025
Graphene nanoplatelets enhance neuronal differentiation of human bone marrow mesenchymal stem cells.
Article in Biological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Dynamic Tuning of MSC-Based Scaffolds for Neurological Protection After Brain or CNS Injury.Life (Basel, Switzerland) · 2026Review
- Photo Crosslinkable Hybrid Hydrogels for High Fidelity Direct Write 3D Printing: Rheology, Curing Kinetics, and Bio-Scaffold Fabrication.Journal of functional biomaterials · 2026Article
- Guiding Cell Growth: Graphene-Patterned Polymeric Substrates for Enhanced Tissue Proliferation.Nanotechnology, science and applications · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
Stem cell technology plays a key role in advancing the understanding of neurological treatments and developing disease models that mimic human conditions. Differentiation of human bone marrow mesenchymal stem cells (hBMSCs) into neurons shows promise for treating neurodegenerative diseases. However, improving the functionality of these nerve cells remains a challenge. Graphene nanoplatelets (GNPs), with their excellent conductivity and biocompatibility, can enhance neuronal differentiation. This study examines the effect of GNPs on hBMSC differentiation. Cells cultured with varying GNP concentrations were assessed at 4 and 7 days using RT-qPCR and immunocytochemistry for neuronal markers MAP2, Nestin, and Tuj1. Results show that GNPs enhance marker expression and promote differentiation. Lower GNP concentrations maintained viability, while higher concentrations were detrimental. Morphological changes and increased fluorescence were observed with a 0.4 µg/ml GNP coating. Calcium imaging with Fluo4-AM indicated increased neuronal activity, underscoring GNPs' role in neuronal maturation. These findings suggest GNPs can drive stem cell differentiation toward neurons, offering new therapeutic potential for neurodegenerative diseases.
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Registered trials
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