ArticleJournal of nanobiotechnology2025
HAMA-SBMA hydrogel with anti-inflammatory properties delivers cartilage organoids, boosting cartilage regeneration.
Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Exploring cartilage development and disease models: applications of cartilage organoids.Inflammation and regeneration · 2026Review
- Patient-Derived 3D-Bioprinted Intrahepatic Cholangiocarcinoma Models Recapitulate Tumor Autologous Traits and Predict Personalized Adjuvant Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- 3D printed HAMA/GelMA/lignosulfonate hydrogel integrating oxygen-releasing and antioxidative modules for liver regeneration.Journal of nanobiotechnology · 2026Article
- Cartilage organoids bridging bench to bedside: A steroid-free strategy for early osteoarthritis repair.Materials today. Bio · 2026Article
- Molecular Mechanisms of Chondrocyte Hypertrophy Mediated by Physical Cues and Therapeutic Strategies in Osteoarthritis.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Cartilage tissue lacks blood supply, which limits its ability to self-repair. Cartilage organoid (CO) technology, which replicates the structure and function of cartilage, holds significant promise. However, it is essential to maintain cellular function and ensure secure fixation at the site of injury. Therefore, we loaded allogeneic bone marrow mesenchymal stem cells (BMSCs) onto decellularized extracellular matrix microparticles of porcine articular cartilage (CEP) to construct CO-CCO, which demonstrated characteristics of articular cartilage. Additionally, betaine sulfonate methacrylate (SBMA) was incorporated into hyaluronic acid methacrylate (HAMA) to synthesize a novel hydrogel, HAMA-SBMA (HS), characterized by its adhesive properties, promotion of chondrogenesis, and inhibition of inflammation. In Vivo studies revealed that the combination of HS and CCO (HS + CCO) exhibited excellent repair efficacy in both rat and sheep models of cartilage defects. Mechanistically, we found that HS + CCO promoted cartilage repair by activating the Frizzled-related protein (Frzb), which inhibited inflammatory factors and enhanced the expression of the adhesion factor integrin ɑ5β1. This strategy, which combines hydrogels and organoids, enhances cartilage repair, offering substantial potential for clinical applications in cartilage regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.