ArticleBMC public health2025
Impact of multi-metal exposure on blood pressure: a mediation analysis through oxidative stress markers in China's Southern Jiangxi Province.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Column switching liquid chromatography dual mass spectrometry system for simultaneous untargeted metabolomics and targeted exposomics.Nature communications · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypertension is a prevalent condition that contributes significantly to the global disease burden. Recent research endeavors have been investigating the potential causal link between metal exposure and the development of hypertension, yet consensus remains elusive. Nevertheless, studies examining the interplay among metal exposure, hypertension, and oxidative stress are relatively limited. This study utilized data from a cross-sectional survey conducted in southern Jiangxi Province, China. We evaluated urinary concentrations of 19 metals, including aluminum and manganese, in conjunction with measurements of systolic and diastolic blood pressures, as well as three oxidative stress biomarkers: glutathione peroxidase (GSH), superoxide dismutase (SOD), and malondialdehyde (MDA). In the monometallic model, chromium, iron, manganese, and molybdenum exhibited positive correlations with blood pressure. These findings were consistent in the mixed exposure model. Conversely, all the aforementioned metals exhibited a negative correlation with GSH and SOD, while demonstrating a positive correlation with MDA. Mediation effect analysis revealed that GSH and SOD mediated the relationships between urinary concentrations of aluminum, iron, manganese, and antimony and blood pressure. In contrast, MDA mediated the associations between urinary silver and antimony and blood pressure. Furthermore, GSH and SOD were identified as mediators in part of the relationship between mixed metal exposure and blood pressure, with mediation rates of 19.09% for GSH and 27.36% for SOD. The results of this study suggest that exposure to both individual and combined metals effects blood pressure levels, which are further associated with changes in oxidative stress levels. Moreover, oxidative stress levels may modulate the changes in blood pressure related to metal exposure, providing a basis for further investigation into the health risks associated with these metal exposures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.