ArticleBMC women's health2025
The etiology differs regards to the locations of the lesion: a clinical experience of 1350 patients with adenomyosis confirmed by postoperative pathology.
Article in BMC women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Sphingomonas paucimobilis-Driven Epithelial-Endothelial Transition in Adenomyosis Pathogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Association between adenomyosis subtypes and concurrent endometrial lesions: a propensity score-matched retrospective study.Frontiers in endocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundDespite proposed mechanisms hypotheses, the etiology of adenomyosis remains unclear. The limited efficacy of current therapeutic approaches may stem from insufficient understanding of its pathobiological underpinnings and the pronounced heterogeneity in clinical presentation and treatment responsiveness among subtypes. This study seeks to compare clinical and sonographic profiles of adenomyosis subtypes to elucidate distinct disease mechanisms and inform subtype-specific management strategies.
methodsIn this retrospective cohort of 1,350 surgically treated and pathologically confirmed adenomyosis cases (2017-2022), patients were categorized into diffuse versus focal and anterior versus posterior lesion groups according to sonographic features. Comparative analyses of demographics, symptomatology, concurrent gynecological conditions, and laboratory profiles were conducted to delineate subtype-specific patterns.
results1074 (79.56%) had a definitive adenomyotic sonographic signs, with 329 (30.63%) focal adenomyosis and 745 (69.37%) diffuse adenomyosis. Multivariate logistic regression analysis revealed that, compared with focal adenomyosis, diffuse adenomyosis were older (OR, 1.09; 95%CI: 1.06-1.12), had more pregnancies (OR, 1.22; 95%CI: 1.11-1.33), higher BMI (OR, 1.05; 95%CI: 1.00-1.09), long course of disease (OR, 1.06; 95%CI: 1.02-1.11) and higher risk of moderate to severe dysmenorrhea (OR, 1.88; 95%CI: 1.36-2.60). Divided to the location of adenomyosis lesion indicated by sonographic, patients in the posterior wall group (n = 418) have higher risk of moderate to severe dysmenorrhea (OR, 1.88; 95% CI: 1.36-2.60), more endometriosis combination (OR, 3.24; 95%CI: 1.85-5.68) and intraoperative blood loss (OR, 1.001; 95%CI: 1.001-1.003).
conclusionBy stratifying adenomyosis into diffuse/focal and anterior/posterior subtypes, we identified distinct clinical-pathological profiles: (1) Diffuse adenomyosis was independently associated with older age, higher gravidity, and severe dysmenorrhea, suggesting a progressive phenotype driven by tissue injury mechanisms; (2) Posterior lesions exhibited a 3.24-fold risk of concurrent endometriosis and increased surgical complexity, implicating shared pathways with deep infiltrating endometriosis. These findings redefine adenomyosis as a heterogeneous disorder with subtype-specific pathophysiology, advocating for tailored therapeutic strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.