ArticleBMC oral health2025
Cross-sectional associations between vitamin D status and periodontitis in adults in Northern Norway: The Tromsø Study 2015-2016.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Impact of Adjunctive Air-Polishing on Periodontal Status in Patients with Low Vitamin DJournal of clinical medicine · 2025Article
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Abstract
backgroundVitamin D is involved in the immune system by regulating inflammatory processes. Over the recent decades, there has been an increase in studies investigating the potential influence of vitamin D status on inflammatory diseases and conditions. However, research on the link between vitamin D and periodontitis remains scarce. Hence, we aimed to examine the relationship between serum 25(OH)D levels and periodontitis in an adult population in Northern Norway.
methodsThe study was based on cross-sectional data from a population-based study: the seventh Tromsø study, conducted in 2015 - 2016. Eligible participants were adults ( ≥ 40 years old) who had both a valid periodontal diagnosis and data on serum 25(OH)D levels, giving a total study sample of n = 3,693 participants (51.4% women). Periodontitis was defined according to the 2017 AAP/EFP classification system. Two groups were compared: no-periodontitis/stage I periodontitis versus stages II-III/IV periodontitis. Using a bivariate logistic regression analysis, the association between these two groups and serum 25(OH)D was tested, controlling for age, sex, smoking, toothbrushing frequency, and socioeconomic status. Periodontal pockets of ≥ 5 mm and their association with serum 25(OH)D were also tested.
resultsAbout 89% were classified as having periodontitis, and 51.6% had stages II-III/IV periodontitis. About 4% of the participants were at deficient levels of serum 25(OH)D (< 30 nmol/L). Levels of serum 25(OH)D of < 30 nmol/L were associated with periodontitis stage II-III/IV (odds ratio [OR] 1.53, 95% confidence interval [CI]: 1.03-2.28). Stratified by when the season serum 25(OH)D was measured (March-September vs October-February), the summer strata was significantly associated with periodontitis II-III/IV (30-50 nmol/L = OR 1.31, 95% CI:1.05-1.63, p = 0.018). Vitamin D deficiency and insufficiency were associated with having at least one periodontal pocket of ≥ 5 mm (< 30 nmol/L = 1.78, 95% CI:1.22-2.60, p = 0.003: 30-50 nmol/L = OR was 1.23, 95% CI:1.03-1.47, p = 0.020, respectively).
conclusionIn this Norwegian adult population, blood 25-hydroxy vitamin D [25(OH)D] levels were associated to periodontitis stage II-III/IV and a periodontal pocket depth of ≥ 5 mm.
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