ArticleBMC pregnancy and childbirth2025
Study protocol. TRAAPREVIA-TRAnexamic acid for preventing blood loss following a cesarean delivery in women with a placenta pREVIA or low-lying placenta: a multicenter randomized, double blind, placebo controlled trial.
Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04304625 (TRAnexamic Acid for Preventing Blood Loss Following a Cesarean Delivery in Women With Placenta pREVIA), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
TRAnexamic Acid for Preventing Blood Loss Following a Cesarean Delivery in Women With Placenta pREVIA: a Multicenter Randomised, Double Blind Placebo Controlled Trial
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlacentas that are previa or low-lying are a major cause of severe postpartum hemorrhage (PPH). Tranexamic acid, by inhibiting the fibrinolytic pathway and protecting blood clots from degradation, is a promising drug for preventing blood loss after childbirth, especially in high-risk conditions. It remains unclear whether tranexamic acid would decrease the incidence of severe PPH among women with placentas that are previa or low-lying. METHODS AND
designThis multicenter, double-blind, randomized controlled trial with two parallel groups will include 1380 women with placenta previa or a low-lying placenta and a cesarean delivery at a term ≥ 32 weeks, modeled on our previous study of tranexamic acid administered after cesarean deliveries (TRAAP2). Women with high antenatal suspicion of placenta accreta spectrum will not be included. Treatment (either tranexamic acid 1 g or placebo) will be administered intravenously just after birth. All women will also receive a prophylactic uterotonic agent. The primary outcome will be the incidence of a red blood cell transfusion before discharge. This study will have a 90% power to show a 33% reduction in the incidence of transfusion, from 20.0% to 13.4%. DISCUSSION: This large multicenter, randomized placebo-controlled trial aims to determine with adequate power if the prophylactic use of tranexamic acid among women with cesarean delivery and a placenta that is previa or low-lying would decrease the incidence of transfusion.
trial registrationClinicalTrials.gov NCT04304625 (March 9, 2020).
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