ArticleDigestive diseases and sciences2025
Cross-Trait Cross-Genome Cross-Organ Analysis of Gastrointestinal Disorders and Depression.
Article in Digestive diseases and sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe aim of this study was to explore the shared genetic architecture between inflammatory bowel disease and depression and other upper gastrointestinal dysfunctions and inflammatory diseases, and to identify shared risk loci, potential key tissues, and associated genetic mechanisms to study.
methodsBased on pooled data from a large-scale genome-wide association study (GWAS), we observed a genetic correlation between inflammatory bowel disease and depression and other upper gastrointestinal tract dysfunctions and inflammatory disorders and performed cross-trait pleiotropy analyses to detect shared pleiotropic loci and genes. In addition, we performed a series of functional annotation and tissue-specific analyses to determine the impact of pleiotropic genes. Genetic power enrichment analysis was used to detect key immune cells and tissues. Finally, immunological associations between these diseases were explored using an immunolocalization approach.
resultsOur study highlights the existence of shared genetic mechanisms between depression, IBS, GORD, chronic gastritis, and IBD. A total of 160 promising pleiotropic loci were identified at the genome-wide significance level (P: 5 × 10
conclusionOur study demonstrates the existence of a genetic association between symptomatic bowel disease and depression and other upper gastrointestinal tract dysfunctions and inflammatory disorders and reveals underlying immunomodulatory mechanisms.
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