Evidence map›Paper›PMID 40447960›Full record

ArticleAAPS PharmSciTech2025

Grape Seed Oil Microemulsion for Improved Skin Delivery of Resveratrol.

Marianne A P C Nogueira, Camila O Cardoso, Lucas F F Albuquerque, Marcilio Cunha-Filho, Tais Gratieri, Guilherme M Gelfuso

Abstract read
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In one paragraph

Article in AAPS PharmSciTech, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marianne A P C NogueiraLaboratory of Food, Drug and Cosmetics (LTMAC), School of Health Sciences, University of Brasília, Campus Universitário Darcy Ribeiro, S/N. 70910-900, Asa Norte, Brasília, DF, Brazil.
Camila O CardosoLaboratory of Food, Drug and Cosmetics (LTMAC), School of Health Sciences, University of Brasília, Campus Universitário Darcy Ribeiro, S/N. 70910-900, Asa Norte, Brasília, DF, Brazil.
Lucas F F AlbuquerqueLaboratory of Food, Drug and Cosmetics (LTMAC), School of Health Sciences, University of Brasília, Campus Universitário Darcy Ribeiro, S/N. 70910-900, Asa Norte, Brasília, DF, Brazil.
Marcilio Cunha-FilhoLaboratory of Food, Drug and Cosmetics (LTMAC), School of Health Sciences, University of Brasília, Campus Universitário Darcy Ribeiro, S/N. 70910-900, Asa Norte, Brasília, DF, Brazil.
Tais GratieriLaboratory of Food, Drug and Cosmetics (LTMAC), School of Health Sciences, University of Brasília, Campus Universitário Darcy Ribeiro, S/N. 70910-900, Asa Norte, Brasília, DF, Brazil.
Guilherme M GelfusoLaboratory of Food, Drug and Cosmetics (LTMAC), School of Health Sciences, University of Brasília, Campus Universitário Darcy Ribeiro, S/N. 70910-900, Asa Norte, Brasília, DF, Brazil. gmgelfuso@unb.br.ORCID http://orcid.org/0000-0002-1924-7885

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Given the anti-inflammatory properties of Resveratrol, this paper proposes developing a grape seed oil-in-water microemulsion (ME) for topical administration to treat inflammatory skin pathological conditions. Thermal analyses confirmed compatibility between Resveratrol, grape seed oil, Tween 80, and Span 80 used in the formulations. Two compositions (ME1 and ME2) were selected from a pseudo-ternary diagram prepared by components titration. ME1 (50% water, 35% surfactant, 15% oil) and ME2 (60% water, 30% surfactant, 10% oil) showed mean droplet sizes of 23.1 ± 0.7 nm and 24.9 ± 1.7 nm (PdI = 0.34 and 0.47), zeta potential between -11.7 ± 0.5 and -13.6 ± 0.9 mV, and pH values of 6.2 ± 0.5 and 7.1 ± 1.1, respectively. Rheological analyses revealed Newtonian behavior and low viscosity, with physical stability for 60 days at room temperature. In vitro drug permeation studies using porcine skin demonstrated that ME increased Resveratrol penetration into deeper skin layers by fourfold (p < 0.001) compared to the control solution (ME1: 2.9 ± 0.1 μg/cm

Indexed as

Plant OilsResveratrolSkinStilbenesVitisAdministration, CutaneousAnimalsChemistry, PharmaceuticalDrug Delivery SystemsEmulsionsGrape Seed ExtractHexosesParticle SizePolysorbatesSkin AbsorptionSurface-Active AgentsEmulsionsGrape Seed ExtractHexosesPlant OilsPolysorbatesResveratrolStilbenesSurface-Active AgentsWaterdrug deliverymicroemulsionresveratrolskin permeationtopical administration

Identifiers

PMID40447960

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.