ArticleClinical rheumatology2025
Multidimensional assessment of Juvenile Sjögren disease.
Article in Clinical rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Nailfold Videocapillaroscopy in Pediatric Rheumatology: Established Roles, Emerging Applications, and Future Perspectives.Balkan medical journal · 2026Review
- Pediatric Sjögren's Disease: Literature Review and Diagnostic Challenges in an Uncommon Case.Diagnostics (Basel, Switzerland) · 2026Article
- NeuroPORTRESS: prevalence, clinical spectrum, and factors associated with neurological involvement in Sjögren's disease.Frontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aims to provide a multidimensional assessment of juvenile Sjögren's disease (jSjD), focusing on diagnostic and management processes through various instrumental tests.
methodsA cross-sectional and retrospective study was conducted on 21 jSjD patients diagnosed between June 2016 and September 2023. In addition, 37 healthy children were included only for comparison of nailfold videocapillaroscopy (NVC) findings. Clinical data, parotid gland ultrasound (US), NVC, salivary gland biopsy, and Schirmer test results were analyzed.
resultsPositive correlations were found between parotitis scores in parotid gland US and bizarre capillary, neoangiogenesis, and microhemorrhage scores in NVC (r = 0.35, 0.32, 0.52; p < 0.05). Diagnostic delay was associated with higher parotitis frequency and scores in US (p = 0.025) and increased dilated capillaries in NVC (p < 0.05). Clinically evident parotitis correlated with higher parotitis frequency in US (p = 0.009) and higher parotitis scores (r = 0.480, p = 0.051). Higher ESSDAI scores at diagnosis correlated with increased parotitis frequency and scores in US (p = 0.001), with higher scores in patients with high disease activity (p < 0.05). ENA-positive patients had higher parotitis scores in US (p = 0.022) and increased cross capillaries in NVC (p = 0.024). Capillary density was lower in the jSjD group compared to healthy controls (p = 0.021), with healthy children having higher median capillary density (p = 0.005). Dilated, bushy, bizarre capillaries, and microhemorrhages were significantly higher in the jSjD group (p < 0.001).
conclusionEarly and accurate diagnosis is crucial for managing jSjD. The integration of US and NVC provides a comprehensive framework for detecting glandular and microvascular abnormalities, emphasizing the need for multidimensional approach. Key Points • This study provides a multidimensional and comprehensive assessment of Juvenile Sjögren's disease (jSjD) by combining various instrumental tests used in the diagnosis and monitoring of Sjögren's disease. • It is the first study in the literature to demonstrate the connection between glandular and microvascular abnormalities in jSjD patients. • The comparison of nailfold videocapillaroscopy findings in healthy children highlights the pronounced microvascular abnormalities present in jSjD patients. • The results emphasize the importance of early diagnosis and intervention, offering critical insights into the systemic effects and clinical progression of the disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.