Creatine monohydrate supplementation and NOX impact skeletal muscle microvascular blood flow: a pilot study.

Paul A Baker, Holly E Clarke, Cesar A Meza, Mostafa M Ali, Robert C Hickner

Abstract read

In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Paul A BakerDepartment of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, USA.ORCID 0009-0007-4921-8659

Holly E ClarkeDepartment of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, USA.ORCID 0000-0002-3276-596X

Cesar A MezaDepartment of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, USA.ORCID 0000-0003-1173-9620

Mostafa M AliDepartment of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, USA.ORCID 0000-0003-1878-0300

Robert C HicknerDepartment of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, USA. rhickner@fsu.edu.ORCID 0000-0002-2683-1617

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Impaired blood flow and elevated reactive oxygen species (ROS) concentrations, generated primarily from NADPH oxidase (NOX), indicate risk for cardiovascular disease (CVD). Creatine monohydrate (CM) may reduce CVD risk by lowering ROS concentrations and increasing skeletal muscle microvascular blood flow (SMBF). To determine if NOX-derived ROS impairs SMBF and whether five days of CM supplementation reduces in-vivo ROS concentrations and improves SMBF. Seven individuals had two microdialysis probes placed (control (CON) and apocynin (APO): NOX inhibitor) in skeletal muscle to measure in-vivo ROS (Hydrogen Peroxide (H

Indexed as

CreatineMicrocirculationMicrovesselsMuscle, SkeletalNADPH OxidasesAdultDietary SupplementsFemaleHumansHydrogen PeroxideMalePilot ProjectsReactive Oxygen SpeciesRegional Blood FlowYoung AdultCreatineHydrogen PeroxideNADPH OxidasesReactive Oxygen SpeciesErgogenic supplementOxidative stressReactive oxygen speciesVascular function

Identifiers

PMID40447849

DOI10.1007/s00424-025-03090-8

PMCPMC12152020

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.