Evidence map›Paper›PMID 40447844›Full record

ArticleCommunications chemistry2025

Multilayered substructures of a non-enzymatic chemical reaction network for synthesizing sugars.

Genta Chikatani, Hiroaki Nishijima, Yuji Ito, Taizo Ikuta, Kaito Nagita, Hiro Tabata, Takashi Harada, Rika Miyake, Shuji Nakanishi, Yoko Hase

Abstract read
In one paragraph

Article in Communications chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Genta ChikataniResearch Center for Solar Energy Chemistry, Graduate School of Engineering Science, The University of Osaka, Toyonaka, Osaka, Japan.
Hiroaki NishijimaResearch Center for Solar Energy Chemistry, Graduate School of Engineering Science, The University of Osaka, Toyonaka, Osaka, Japan.
Yuji ItoToyota Central R&D Labs. Inc., Nagakute, Aichi, Japan.
Taizo IkutaResearch Center for Solar Energy Chemistry, Graduate School of Engineering Science, The University of Osaka, Toyonaka, Osaka, Japan.
Kaito NagitaResearch Center for Solar Energy Chemistry, Graduate School of Engineering Science, The University of Osaka, Toyonaka, Osaka, Japan.
Hiro TabataResearch Center for Solar Energy Chemistry, Graduate School of Engineering Science, The University of Osaka, Toyonaka, Osaka, Japan.
Takashi HaradaResearch Center for Solar Energy Chemistry, Graduate School of Engineering Science, The University of Osaka, Toyonaka, Osaka, Japan.
Rika MiyakeResearch Center for Solar Energy Chemistry, Graduate School of Engineering Science, The University of Osaka, Toyonaka, Osaka, Japan.
Shuji NakanishiResearch Center for Solar Energy Chemistry, Graduate School of Engineering Science, The University of Osaka, Toyonaka, Osaka, Japan. nakanishi.shuji.es@osaka-u.ac.jp.ORCID http://orcid.org/0000-0002-3313-2689
Yoko HaseResearch Center for Solar Energy Chemistry, Graduate School of Engineering Science, The University of Osaka, Toyonaka, Osaka, Japan. y-hase@mosk.tytlabs.co.jp.ORCID http://orcid.org/0000-0001-8805-7922

Funding

MEXT | Japan Society for the Promotion of Science (JSPS) 19K22232MEXT | Japan Society for the Promotion of Science (JSPS) 22J10537
6 · The paper itself

Abstract

In biological chemical reactions, substructures formed through multi-step enzymatic reactions organize into large chemical reaction networks (CRNs) that produce complex and sophisticated functions. Recently, significant attention has been paid to artificial, non-enzymatic control of multi-step chemical reactions aimed at synthesizing compounds with structural complexity. However, the synergistic effects arising from the activation of different substructures within a CRN by multiple catalysts remain unexplored. Here we focus on the formose reaction as a non-enzymatic CRN to demonstrate that the complementary activation of multiple substructures by distinct catalysts leads to the emergence of novel functions. Statistical analyses of temporal changes in compound concentrations during reactions catalyzed by γ-Al

Identifiers

PMID40447844
PMCPMC12125316

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.