ArticlePediatric research2025
Severity of punctate white matter lesions in preterm infants: antecedents and cerebral palsy prediction.
Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Punctate white matter lesions predict risk for cerebral palsy: further evidence for routine brain MRI in preterm infants.Pediatric research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundThe objectives were to investigate antecedent factors of punctate white matter lesions (PWML) severity on MRI at term-corrected age (CA) and to evaluate its ability to independently predict cerebral palsy (CP) in preterm infants.
methodsWe studied infants born at ≤32 weeks' gestational age [GA] with brain MRI at term CA, a standardized neuromotor exam to determine CP diagnosis, and composite scores from Bayley Scales of Infant and Toddler Development-III(BSID-III) at 2 years CA. MRIs with PWML were manually segmented and volume quantified with high reliability. We correlated >50 perinatal antecedent factors with PWML severity and conducted multivariable regression analyses to assess PWML ability to independently predict neurodevelopmental outcomes at age 2.
resultsOf 392 infants, 28 (7.1%) had PWML; 339 (86%) were assessed at age 2, 39 (11.6%) had CP. Moderate-severe acute histologic chorioamnionitis (HCA), prenatal opioid use, and antenatal corticosteroids were independently associated with PWML severity. Increasing PWML severity was significantly predictive of CP (OR 2.12; 95% CI:1.34,3.37), independent of known predictors, but not BSID-III scores.
conclusionsIncreasing burden of PWML was associated with two-fold risk of CP in preterm infants. We also identified HCA, prenatal opioids, and antenatal corticosteroids as modifiable risk and protective factors for PWML that may be amenable to prevention efforts. IMPACT: Punctate white matter lesions (PWML) are commonly seen on MRI scans in preterm infants, yet the antecedent factors associated with PWML are not well characterized. While prior literature is conflicting on the ability of PWML to predict neurodevelopmental impairments, our study demonstrated that objectively quantified PWML are independently predictive of the development of cerebral palsy. We identified modifiable factors such as histologic chorioamnionitis as a risk factor and antenatal corticosteroids as a protective factor against PWML development. Our findings may facilitate earlier identification of infants at risk for PWML and cerebral palsy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.