SynthesisEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2025
Transdermal buprenorphine patch in the management of post-operative pain in orthopaedic patients: a systematic review looking at efficacy, safety, adverse effects and cost-benefit analysis.
Synthesis in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The trial behind it
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Authors and funding
4 authors.
Funding
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Abstract
aimThis systematic review aims to evaluate the safety and efficacy of transdermal buprenorphine patches for pain management in post-operative orthopaedic patients compared to conventional analgesics and placebo.
methodsA comprehensive search was conducted in Medline, Embase and Cochrane CENTRAL, covering studies up until September 2024. Studies included randomised controlled trials comparing transdermal buprenorphine with standard analgesics in post-operative orthopaedic patients. Two reviewers independently screened and extracted data, assessing outcomes related to pain relief, side effects, patient satisfaction and the need for additional analgesia. Risk of bias was assessed using the Cochrane RoB2. Cost-benefit analysis was conducted retrospectively.
resultsFrom 921 initial records, 579 were screened, and 13 studies met the inclusion criteria after eligibility assessment. These studies, covering various orthopaedic surgeries, evaluated transdermal buprenorphine against conventional analgesics like tramadol, fentanyl and NSAIDs. Buprenorphine consistently provided effective pain relief comparable to other opioids, with fewer respiratory and gastrointestinal side effects, particularly in elderly patients. Patient satisfaction was higher due to the steady analgesic effect and reduced need for additional analgesia. Risk of bias was rated as high in 4 studies, medium in 5 and low in 4.
conclusionTransdermal buprenorphine is a viable alternative for post-operative pain management in orthopaedic patients, especially the elderly. Its safety profile and consistent analgesia make it a valuable option for reducing opioid-related complications. Further research is needed to expand on these findings across diverse clinical settings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.