Evidence map›Paper›PMID 40447786›Full record

ArticleJournal of neurology2025

From checkboxes to emojis: a novel approach to patient-reported outcomes in multiple sclerosis.

Nur Neyal, Katelynn J Krey, Holly A Morrison, Nabeela Nathoo, Elizabeth J Atkinson, Jiye Son, Eoin P Flanagan, Sean J Pittock, Ugur Uygunoglu, Orhun H Kantarci and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nur NeyalDepartment of Radiology, Mayo Clinic, 200 1 st St SW, Rochester, MN, 55905, USA.ORCID http://orcid.org/0000-0003-2959-4271
Katelynn J KreyDepartment of Materials Science and Biomedical Engineering, University of Wisconsin-Eau Claire, Eau Claire, WI, USA.ORCID http://orcid.org/0009-0008-6290-0449
Holly A MorrisonCenter for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, Rochester, MN, USA.
Nabeela NathooDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-6446-1146
Elizabeth J AtkinsonDepartment of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-1191-3775
Jiye SonDepartment of Radiology, Mayo Clinic, 200 1 st St SW, Rochester, MN, 55905, USA.
Eoin P FlanaganDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-6661-2910
Sean J PittockDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-6140-5584
Ugur UygunogluDepartment of Neurology, Istanbul University Cerrahpaşa School of Medicine, Istanbul, Türkiye.ORCID http://orcid.org/0000-0003-2866-4004
Orhun H KantarciDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-7038-8133
Burcu ZeydanDepartment of Radiology, Mayo Clinic, 200 1 st St SW, Rochester, MN, 55905, USA. zeydan.burcu@mayo.edu.ORCID http://orcid.org/0000-0002-2270-9868

Funding

Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's DiseaseU54AG044170 · NIA · MAYO CLINIC ROCHESTER · PI KAPOOR, EKTA · 2018 to 2022
$7.7M
Utilizing epidemiology, imaging and fluid biomarkers in MOG antibody-associated disease to inform prognosis, pathogenesis and therapeuticsR01NS113828 · NINDS · MAYO CLINIC ROCHESTER · PI Eoin P Flanagan · 2020 to 2026
$2.4M
Mayo Clinic Building Interdisciplinary Research Careers in Women’s HealthK12AR084222 · NIAMS · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL · 2023 to 2024
$733k
NIAMS NIH HHS K12 AR084222NIA NIH HHS U54 AG044170NIH HHS K12 AR084222NIH HHS U54 AG044170NINDS NIH HHS R01 NS113828
6 · The paper itself

Abstract

backgroundPatient-reported outcome measures (PROMs) improve multiple sclerosis (MS) management by reflecting patients' perspectives of their disease. Mayo Clinic Electronic Emoji Based Neurological Impairment Status (MEBNIS) is a short PROM consisting of four equally-weighted domains (Memory

objectiveTo investigate the correlations of MEBNIS with patient-reported, examination-based, performance-based, and radiological metrics of disease severity in persons with MS (pwMS).

methodsPwMS (n = 195) prospectively completed MEBNIS, Expanded Disability Status Scale (EDSS), MS Functional Composite (MSFC) and its subtests [25-Foot Walk Test (25FWT), 9-Hole Peg Test (9HPT), Paced Auditory Serial Addition Test (PASAT)], Beck Depression Inventory (BDI), Fatigue Questionnaire (FQ), and Epworth Sleepiness Scale (ESS) between May 2021 and May 2024. Participants also underwent brain MRIs. Correlations were summarized using Spearman's rank correlation coefficients.

resultsMemory

conclusionsAs a novel visual PROM, MEBNIS correlates with established patient-reported, examination-based, performance-based, and radiological metrics of MS severity. It offers a fast, intuitive, and accessible multi-domain evaluation of impairment and disease severity in MS, applicable to both clinical practice and clinical trials as a potential digital tool.

Indexed as

Multiple SclerosisPatient Reported Outcome MeasuresAdultDisability EvaluationFatigueFemaleHumansMaleMiddle AgedProspective StudiesSeverity of Illness IndexDigital toolDisease severityEmojiMultiple sclerosisPatient-reported outcome

Identifiers

PMID40447786
PMCPMC12279282

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.