ArticleScientific reports2025
Measurement of macrophage phagocytic capacity by quantifying maximum membrane extension using an opsonized capillary tube assay.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Microneedle-Based Analysis Reveals Polarity-Dependent Spatial Regulation of Macrophage Phagocytosis.Micromachines · 2026Article
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5 authors.
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Abstract
The zipper mechanism explains phagocytosis as sequential ligand-receptor interactions between macrophages and antigens, followed by the cell membrane extension for phagosome formation. Hence, the ability of macrophages to innate immunity is restricted by their capacity for engulfment related to the expansion limit of their membranes. However, the maximum expansion ability of macrophage membranes and their relationship with the phagocytosis capacity has not been rigorously investigated yet because of the lack of quantitative measurement methods of maximum cell expansion. Here, we have developed an opsonized capillary tube assay and evaluated the maximum membrane extension on the opsonized inner surface of capillary tubes from the inner round area attached to the macrophage surface. When the engulfment started, the cell membrane in the inner circle of the capillary head expanded up to 10.64 times in opsonized capillary tubes regardless of the inner diameter differences of 3 to
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