Evidence map›Paper›PMID 40447691›Full record

ArticleScientific reports2025

Barium nanoparticles enhance efficacy of external beam radiation therapy in a preclinical basal-like mammary cancer mouse model.

Jonas Albers, Andrea Markus, Angelika Svetlove, Alexander Kraupner, Andreas Briel, Frauke Alves, Christian Dullin

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jonas AlbersInstitute for Clinical and Interventional Radiology, University Medical Center Goettingen, Göttingen, Germany.
Andrea MarkusTranslational Molecular Imaging, Max-Plank-Institute for Multidisciplinary Sciences, Göttingen, Germany.
Angelika SvetloveTranslational Molecular Imaging, Max-Plank-Institute for Multidisciplinary Sciences, Göttingen, Germany.
Alexander KraupnerNanoPet Pharma GmbH, Berlin, Germany.
Andreas BrielNanoPet Pharma GmbH, Berlin, Germany.
Frauke AlvesInstitute for Clinical and Interventional Radiology, University Medical Center Goettingen, Göttingen, Germany.
Christian DullinInstitute for Clinical and Interventional Radiology, University Medical Center Goettingen, Göttingen, Germany. christian.dullin@protonmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

External beam radiation therapy (RT) using high energy x-rays is a commonly applied cancer treatment. A major advantage of RT is its unspecific nature which allows using RT in many cancer entities. RT however causes the well-known side effects on healthy tissue in the irradiated areas. Therefore, enhancing the efficacy of RT at the tumor site while simultaneously lowering the overall radiation dose has been a long term goal. Heavy metal-based contrast agents such as gold, hafnium, gadolinium and iodine have already been proposed as radio-enhancers and are partially in clinical trials. Here we present barium sulphate (BaSO

Indexed as

BariumBarium SulfateMetal NanoparticlesNanoparticlesAnimalsCell Line, TumorContrast MediaDisease Models, AnimalFemaleMiceBariumBarium SulfateContrast MediaContrast enhancerNanoparticleRadiation therapy

Identifiers

PMID40447691
PMCPMC12125400

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.