ArticleScientific reports2025
Transcriptome sequencing reveals the expression profiles of lncRNAs and mRNAs in goat skin tissues with different types of wool coats.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Multispecies Transcriptomics of Mammalian Skin Reveals Conserved and Divergent Regulatory Features.International journal of molecular sciences · 2026Article
- Melatonin Regulates the Proliferation of Liaoning Cashmere Goat Skin Fibroblasts via the lncRNA16913.1-chi-miR-195-5p-FZD6 Axis.Animals : an open access journal from MDPI · 2026Article
- Transcriptomic Analysis Reveals AKT1 Upregulation in Inner Mongolian Cashmere Goats at 12 and 15 Months of Age.Veterinary sciences · 2026Article
- Comparative Skin Transcriptomics Reveals Key Regulators of Cashmere Fiber Production in Inner Mongolian Goats.Animals : an open access journal from MDPI · 2026Article
- Multi-omics and AI-driven advances in miRNA-mediated hair follicle regulation in cashmere goats.Frontiers in veterinary science · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The diverse coat types of cashmere goats significantly influence cashmere yield, yet the regulatory mechanisms mediated by non-coding RNAs (ncRNAs) remain poorly characterized. In this study, we collected skin tissues from two distinct coat types (CHLC_ESA and CHSC_ESA) of The Jinlan Cashmere Goat for transcriptome sequencing analysis. Our findings revealed 130 differentially expressed (DE) lncRNAs and 341 DE mRNAs. GO functional enrichment analysis uncovered some crucial terms such as keratin filament, intermediate filament, cytokine activity, and cytokine receptor binding, along with two pivotal DE lncRNAs: TCONS_00050130 and TCONS_00050142. Furthermore, KEGG pathway analysis identified several important pathways including the Estrogen signaling pathway, Amino sugar and nucleotide sugar metabolism, Adipocytokine signaling pathway, and cytokine-cytokine receptor interaction. Lastly, by constructing a ceRNA regulatory network among DE lncRNAs and DE mRNAs, we identified multiple ceRNA regulatory axes targeting genes such as EPPK1, IRF4, CCL20, and CXCR7. These mechanistic insights not only advance our understanding of ncRNA-mediated hair follicle biology but also provide actionable targets for precision breeding strategies to enhance cashmere quality and yield across caprine species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.