ArticleScientific reports2025
CXCL12 links bladder cancer and diabetes as a potential biomarker.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- Bladder Cancer Biomarkers: Recent Advances in Early Detection, Treatment Prediction, and Prognosis.Oncology research · 2026Review
- Integrative Transcriptomic Analysis Identifies CXCL12 as a Candidate Hub Gene Associated with CD4⁺ T-Cell Immune Network Remodeling in Secondary Lymphedema.Journal of inflammation research · 2026Article
- The interplay of dietary sugar, chronic inflammation, and bladder cancer: mechanistic insights, evidence, and prevention strategies.Frontiers in immunology · 2026Review
- Diseases burden and trends of bladder cancer attributable to behavioral and metabolic factors among global and Chinese population, 1990-2021: results from the global burden of disease study 2021.Journal of health, population, and nutrition · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Bladder cancer (BLCA) and diabetes mellitus (DM) are two prevalent diseases that may share molecular mechanisms, suggesting potential links between metabolic disorders and cancer. Using bioinformatics approaches, we integrated multiple databases to identify common genes between BLCA and DM, screening for potential biomarkers. CXCL12 (C-X-C motif chemokine 12, also known as stromal cell-derived factor 1 , SDF-1) was ultimately identified as a key gene, followed by comprehensive analyses including immune infiltration analysis, functional enrichment analysis, survival analysis, clinicopathological correlation analysis, TIDE immune prediction scoring, and immunophenoscore (IPS) scoring comparison. The results indicate that CXCL12 is associated with altered immune cell function and tumor characteristics under elevated blood glucose levels, influencing the tumor microenvironment and promoting disease progression. The results elucidate the molecular underpinnings of BLCA and DM, establishing a basis for subsequent investigations into common mechanisms and the formulation of targeted therapeutic approaches. Research on shared biomarkers, such as CXCL12, between metabolic diseases and tumors aids in the precise prevention and control of comorbidities' adverse effects on tumor progression. This approach significantly reduces the health burden linked to comorbidities.
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Registered trials
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