ArticleNature communications2025
Birch reductive arylation by mechanochemical anionic activation of polycyclic aromatic compounds.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Diversity-Oriented Two-Step Annulative π-Extension Enables Access to Structurally Complex Nanographenes.Angewandte Chemie (International ed. in English) · 2026Article
- Article
- Unlocking the pineapple aroma of Cili fruit: Identification of key odorants in a unique Cili fruit with pineapple flavor.Food chemistry: X · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Birch reduction is a well-known process for transforming aromatic compounds. The reduction of aromatic rings using alkali metals produces anionic species that react with protons or electrophiles. Generally, this reaction is accompanied by significant limitations in the available nucleophiles, since in most cases only alkyl halides and silyl chlorides are available. In particular, the arylation of unfunctionalized polycyclic aromatic hydrocarbons (PAHs), so-called Birch reductive arylation, has not yet been investigated. Herein, we report a Birch reductive arylation by mechanochemical anionic activation using a lithium(0) wire, followed by addition of various fluoroarenes. Specifically, not only Birch reductive arylation products but also formal C-H arylation products can be obtained from unfunctionalized PAHs, achieving one-pot annulative π-extension to give nanographenes. This process is a unique reaction that is rarely achieved in solution, and shows the interesting reactivity of lithium metal and fluoroarenes in the solid state.
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Registered trials
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