Evidence map›Paper›PMID 40447445›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Developmental Olfactory Dysfunction and Abnormal Odor Memory in Immune-Challenged

Fiona Parbst, Johanna K Kostka, Anne Günther, Yu-Nan Chen, Ileana L Hanganu-Opatz, Sebastian H Bitzenhofer

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Post-laryngectomy videofluoroscopic assessment in relation to olfactory rehabilitation through the physiological olfactory recovery technique.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2026
    Observational
  2. Mapping prefrontal afferents along development.Frontiers in neuroscience · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fiona ParbstInstitute of Developmental Neurophysiology, Center for Molecular Neurobiology Hamburg, Hamburg Center of Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany.
Johanna K KostkaInstitute of Developmental Neurophysiology, Center for Molecular Neurobiology Hamburg, Hamburg Center of Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany.ORCID 0000-0001-9437-4959
Anne GüntherInstitute of Developmental Neurophysiology, Center for Molecular Neurobiology Hamburg, Hamburg Center of Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany.
Yu-Nan ChenInstitute of Developmental Neurophysiology, Center for Molecular Neurobiology Hamburg, Hamburg Center of Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany.
Ileana L Hanganu-OpatzInstitute of Developmental Neurophysiology, Center for Molecular Neurobiology Hamburg, Hamburg Center of Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany hangop@zmnh.uni-hamburg.de sebastian.bitzenhofer@zmnh.uni-hamburg.de.
Sebastian H BitzenhoferNeural Circuit Physiology, Center for Molecular Neurobiology Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg 20251, Germany hangop@zmnh.uni-hamburg.de sebastian.bitzenhofer@zmnh.uni-hamburg.de.ORCID 0000-0003-0736-6251

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuronal activity in the olfactory bulb (OB) drives coordinated activity in the hippocampal-prefrontal network during early development. Inhibiting OB output in neonatal mice disrupts functional development of the hippocampal formation as well as cognitive abilities. These impairments manifest early in life and resemble dysfunctions of the hippocampus and the prefrontal cortex that have been linked to neuropsychiatric disorders. Thus, we investigated OB activity during early development in a disease mouse model and asked whether activity disruptions might contribute to the dysfunctional development of the hippocampal-prefrontal network. We addressed this question by combining in vivo electrophysiology with behavioral assessment of immune-challenged

Indexed as

MemoryMemory DisordersNerve Tissue ProteinsOlfaction DisordersOlfactory BulbOlfactory PerceptionAnimalsFemaleHippocampusMaleMiceMice, Inbred C57BLOdorantsPrefrontal CortexSmellDisc1 protein, mouseNerve Tissue ProteinsdevelopmentDisc1hippocampusneuropsychiatricolfactionprefrontal cortex

Identifiers

PMID40447445
PMCPMC12178285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.