Evidence map›Paper›PMID 40447325›Full record

ArticleThorax2025

Lung development genes, adult lung function and cardiovascular comorbidities.

Laura Portas, Mohammad Talaei, Charlotte Dean, Nay Aung, Matthew David Hind, Alfred Pozarickij, Robin G Walters, China Kadoorie Biobank Collaborative Group, Peter Gj Burney, Steffen Petersen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thorax, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Laura PortasNational Heart and Lung Institute, Imperial College London, London, UK Laura.Portas@ndph.ox.ac.uk.ORCID 0000-0003-1789-1893
Mohammad TalaeiWolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0002-6901-3665
Charlotte DeanNational Heart and Lung Institute, Division of Respiratory Science, London, UK.ORCID 0000-0002-8846-5472
Nay AungBarts and The London School of Medicine and Dentistry William Harvey Research Institute, London, UK.
Matthew David HindNational Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0002-9966-9446
Alfred PozarickijNuffield Department of Population Health, University of Oxford, Oxford, UK.
Robin G WaltersNuffield Department of Population Health, University of Oxford, Oxford, UK.
China Kadoorie Biobank Collaborative Group
Peter Gj BurneyNational Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0001-8635-5678
Steffen PetersenCentre for Advanced Cardiovascular Imaging, Barts and The London School of Medicine an Dentistry, London, UK.
Cosetta Minelli *National Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0001-9166-3958
Seif O Shaheen *Wolfson Institute of Population Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.ORCID 0000-0002-7273-8691

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe association between lower adult lung function and increased cardiovascular comorbidity has not been adequately explained. We investigated whether shared developmental signalling pathways, critical to lung development and repair, could partly explain it.

methodsIn UK Biobank (UKB), we performed pairwise colocalisation analysis of variants in 55 lung development genes associated with adult forced vital capacity (FVC) or forced expiratory volume in 1 s (FEV

resultsWe found that 12 of the 55 genes shared the same variant between one (or more) lung function trait and one (or more) cardiovascular trait (H4colocalisation). The direction of effects was always in keeping with our hypothesis (lower lung function-higher cardiovascular risk) for FVC, but not always for FEV

conclusionLung function and cardiovascular traits have shared developmental pathways that may partly explain why lower lung function, especially FVC, is associated with increased cardiovascular risk.

Indexed as

Cardiovascular DiseasesLungAdultBlood PressureCarotid Intima-Media ThicknessComorbidityCoronary DiseaseFemaleForced Expiratory VolumeHumansMaleMiddle AgedUnited KingdomVascular StiffnessVital Capacitylung physiologyrespiratory measurement

Identifiers

PMID40447325
PMCPMC12505039

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.