Feasibility Study of Bioactive Hydrogel Coatings on Ti-6Al-4V Gyroid Scaffolds for Bone Tissue Engineering.

Lisa Schöbel, Maddi Garcia Ayerbe, Christian Polley, Gurutze Arruebarrena, Hermann Seitz, Aldo R Boccaccini

Abstract read

In one paragraph

Article in ACS biomaterials science & engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Lisa SchöbelInstitute of Biomaterials, Department of Materials Science and Engineering, Friedrich Alexander-University Erlangen-Nuremberg, 91056 Erlangen, Germany.ORCID 0000-0003-0391-4089

Maddi Garcia AyerbeFaculty of Engineering, Mondragon University, 20500 Arrasate/Mondragon, Spain.

Christian PolleyChair of Microfluidics, Faculty of Mechanical Engineering and Marine Technology, University of Rostock, 18059 Rostock, Germany.

Gurutze ArruebarrenaFaculty of Engineering, Mondragon University, 20500 Arrasate/Mondragon, Spain.

Hermann SeitzChair of Microfluidics, Faculty of Mechanical Engineering and Marine Technology, University of Rostock, 18059 Rostock, Germany.ORCID 0000-0003-3401-0090

Aldo R BoccacciniInstitute of Biomaterials, Department of Materials Science and Engineering, Friedrich Alexander-University Erlangen-Nuremberg, 91056 Erlangen, Germany.ORCID 0000-0002-7377-2955

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Titanium alloys are commonly used for bone replacement due to their excellent corrosion resistance. However, they can cause stress shielding due to their high stiffness. Consequently, porous titanium scaffolds can be designed to reduce the elastic mismatch with bone, and further hydrogel coatings can be applied to mimic the extracellular microenvironment. In this work, gyroid titanium scaffolds were coated with a bioactive alginate-gelatin hydrogel. The addition of 45S5 bioactive glass enhanced the mechanical properties of the hydrogel and its adhesion strength. Furthermore, the developed hydrogels allowed for the penetration of gyroid scaffolds, demonstrating the potential of bioactive coatings for titanium implants.

Indexed as

Bone and BonesCoated Materials, BiocompatibleHydrogelsTissue EngineeringTissue ScaffoldsTitaniumAlginatesAlloysFeasibility StudiesGelatinHumansAlginatesAlloysCoated Materials, BiocompatibleGelatinHydrogelsTitaniumtitanium alloy (TiAl6V4)Bioactive HydrogelsHard-to-Soft TransitionTriple Periodic Minimal Surface

Identifiers

PMID40447266

DOI10.1021/acsbiomaterials.4c02250

PMCPMC12264767

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.