Evidence map›Paper›PMID 40447138›Full record

ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2025

Comprehensive Clinicopathologic, Morphologic, and Molecular Evaluation and Outcomes in Polymorphous Adenocarcinoma Tumors With Applicability of a 2-Tiered Grading System.

Kartik Viswanathan, Scott Steward-Tharp, Daniel Lubin, Faisal Saeed, Kelly Magliocca, Luvy Delfin, Elizabeth Bilodeau, Ghulam Ilyas, Ronald Ghossein, Bin Xu and 1 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. HER2-low and HER2-ultra-low salivary gland carcinomas: an exploratory study.Virchows Archiv : an international journal of pathology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kartik ViswanathanDepartment of Pathology and Laboratory Medicine, Emory University Hospital Midtown, Atlanta, Georgia; Winship Cancer Institute, Emory University Hospital, Atlanta, Georgia. Electronic address: kartik.viswanathan@emory.edu.
Scott Steward-TharpDepartment of Pathology and Laboratory Medicine, Emory University Hospital Midtown, Atlanta, Georgia; Winship Cancer Institute, Emory University Hospital, Atlanta, Georgia.
Daniel LubinDepartment of Pathology and Laboratory Medicine, Emory University Hospital Midtown, Atlanta, Georgia; Winship Cancer Institute, Emory University Hospital, Atlanta, Georgia.
Faisal SaeedDepartment of Pathology and Laboratory Medicine, Emory University Hospital Midtown, Atlanta, Georgia; Winship Cancer Institute, Emory University Hospital, Atlanta, Georgia.
Kelly MaglioccaDepartment of Pathology and Laboratory Medicine, Emory University Hospital Midtown, Atlanta, Georgia; Winship Cancer Institute, Emory University Hospital, Atlanta, Georgia.
Luvy DelfinDepartment of Pathology and Laboratory Medicine, Emory University Hospital Midtown, Atlanta, Georgia; Winship Cancer Institute, Emory University Hospital, Atlanta, Georgia.
Elizabeth BilodeauDepartment of Pathology and Laboratory Medicine, Emory University Decatur Hospital, Decatur, Georgia.
Ghulam IlyasDepartment of Pathology and Laboratory Medicine, Emory University Johns Creek Hospital, Johns Creek, Georgia.
Ronald GhosseinDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Bin XuDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Nora KatabiDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York. Electronic address: katabin@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Polymorphous adenocarcinoma (PAC) is an uncommon salivary gland tumor demonstrating morphologic diversity, including conventional trabecular/tubular/reticular/single filing, cribriform/solid (cribriform adenocarcinoma of minor salivary gland [CASG]), and papillary (tumor with papillary growth pattern [TPAP]) patterns, with differing molecular alterations and biologic behavior. However, similar to other salivary gland tumors, whether a grading system incorporating mitotic count and necrosis could be applied to PACs is unclear. Retrospective histologic evaluation was performed on a bi-institutional cohort of 154 PACs, and a 2-tiered low-grade/high-g1rade (HG) system, incorporating mitoses ≥ 5 per 2 mm

Indexed as

AdenocarcinomaSalivary Gland NeoplasmsAdolescentAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedNecrosisNeoplasm GradingRetrospective StudiesYoung Adultgrading systemhistomorphologypolymorphous adenocarcinomasalivary gland

Identifiers

PMID40447138
PMCPMC13411138

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.