Evidence map›Paper›PMID 40446801›Full record

ArticleCell reports. Medicine2025

Distinct viral reservoirs and immune signatures in individuals on long-term antiretroviral therapy with perinatally acquired HIV-1.

Benjamin Bone, Nicola Cotugno, Chiara Pighi, Arianna Rotili, Seohyun Hong, Leah Carrere, Elena Morrocchi, Giuseppe Rubens Pascucci, Ce Gao, Nicole Colantoni and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Benjamin BoneThe Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA; Infectious Disease Division, Brigham Women's Hospital, Boston, MA, USA. Electronic address: brb173@med.miami.edu.
Nicola CotugnoClinical Immunology and Vaccinology Unit, IRCCS, Bambino Gesù Children's Hospital, Rome, Italy; Chair of Paediatrics, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy. Electronic address: nicola.cotugno@opbg.net.
Chiara PighiClinical Immunology and Vaccinology Unit, IRCCS, Bambino Gesù Children's Hospital, Rome, Italy.
Arianna RotiliClinical Immunology and Vaccinology Unit, IRCCS, Bambino Gesù Children's Hospital, Rome, Italy; PhD Program in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome "Tor Vergata", Rome, Italy.
Seohyun HongThe Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA.
Leah CarrereThe Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA; Infectious Disease Division, Brigham Women's Hospital, Boston, MA, USA.
Elena MorrocchiClinical Immunology and Vaccinology Unit, IRCCS, Bambino Gesù Children's Hospital, Rome, Italy.
Giuseppe Rubens PascucciClinical Immunology and Vaccinology Unit, IRCCS, Bambino Gesù Children's Hospital, Rome, Italy; Chair of Paediatrics, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Ce GaoThe Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA; Infectious Disease Division, Brigham Women's Hospital, Boston, MA, USA.
Nicole ColantoniClinical Immunology and Vaccinology Unit, IRCCS, Bambino Gesù Children's Hospital, Rome, Italy.
Weiwei SunThe Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA.
Giovanna LeoneTransfusion Unit, IRCCS, Bambino Gesù Children's Hospital, Rome, Italy.
David R CollinsThe Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA.
Mpho J OlatotseThe Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA.
Giovanna Del PrincipeTransfusion Unit, IRCCS, Bambino Gesù Children's Hospital, Rome, Italy.
Toong Seng TanThe Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA.
Melanie LancienThe Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA.
Alessia NeriClinical Immunology and Vaccinology Unit, IRCCS, Bambino Gesù Children's Hospital, Rome, Italy; PhD Program in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome "Tor Vergata", Rome, Italy.
Libera SessaThe Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA; Infectious Disease Division, Brigham Women's Hospital, Boston, MA, USA.
Giulio OlivieriClinical Immunology and Vaccinology Unit, IRCCS, Bambino Gesù Children's Hospital, Rome, Italy; PhD Program in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome "Tor Vergata", Rome, Italy.
Kailey ShapiroThe Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA.
Isabelle RosetoThe Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA; Infectious Disease Division, Brigham Women's Hospital, Boston, MA, USA.
Catherine KoofhethileThe Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA; Infectious Disease Division, Brigham Women's Hospital, Boston, MA, USA.
Elena EmiliChair of Paediatrics, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Stefania BernardiInfectious Diseases Unit, IRCCS, Bambino Gesù Children's Hospital, Rome, Italy.
Ann ChahroudiDepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Paolo RossiChair of Paediatrics, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Bruce D WalkerThe Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA.
Xu G YuThe Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA.
Mathias LichterfeldThe Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA; Infectious Disease Division, Brigham Women's Hospital, Boston, MA, USA. Electronic address: mlichterfeld@mgh.harvard.edu.
Paolo PalmaClinical Immunology and Vaccinology Unit, IRCCS, Bambino Gesù Children's Hospital, Rome, Italy; Chair of Paediatrics, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy. Electronic address: paolo.palma@opbg.net.

Funding

Pediatric Adolescent Virus Elimination (PAVE) Martin Delaney CollaboratoryUM1AI164566 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Ann M Chahroudi, Deborah Persaud · 2021 to 2026
$35.5M
Targeting HIV reservoirs in children with HIVIS DNA and MVA-CMDR vaccinesU01AI135941 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI PALMA, PAOLO, ROBB, MERLIN L · 2018 to 2024
$6.4M
Single-cell Proteogenomic profiling of HIV-1 reservoir cellsR01AI176579 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Mathias Lichterfeld · 2023 to 2026
$4.6M
Immune selection of HIV-1 reservoir cells in human clinical trialsR01AI184094 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Mathias Lichterfeld · 2024 to 2026
$2.7M
NIAID NIH HHS R01 AI176579NIAID NIH HHS R01 AI184094NIAID NIH HHS U01 AI135941NIAID NIH HHS UM1 AI164566
6 · The paper itself

Abstract

Early initiation of antiretroviral therapy (ART) following HIV-1 infection restricts the size of the latent reservoir, following both horizontal and vertical infections. Here, we comprehensively profile the reservoirs and immunological milieus of nine young adults who acquired HIV-1 perinatally and remained on suppressive long-term ART (median: 20 years) since infancy (LeukoHIV cohort). Genome-intact reservoirs are markedly smaller compared to a cohort of adults on suppressive ART started in adulthood, with some LeukoHIV individuals characterized by an absence or near absence of intact proviruses in up to a billion peripheral blood mononuclear cells (PBMCs). Higher frequencies of functional CD56

Indexed as

Anti-Retroviral AgentsHIV-1HIV InfectionsAdultCD8-Positive T-LymphocytesDisease ReservoirsFemaleHumansInfectious Disease Transmission, VerticalKiller Cells, NaturalLeukocytes, MononuclearMaleProvirusesViral LoadVirus LatencyYoung AdultAnti-Retroviral Agentschildrendeep latencyHIVleukophoresislong-term ARTMIP-seqnatural killer cellsperinatal infectionprovirusreservoir

Identifiers

PMID40446801
PMCPMC12208329

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.