Evidence map›Paper›PMID 40446792›Full record

ArticleUltrasonics sonochemistry2025

Visibly acoustic delivery of IR808 into tumor via gas vesicles enhances photothermal therapy efficacy against tumor.

Xin Meng, Yanan Feng, Yuanyuan Wang, Chen Lin, Wei Wang, Sutian Zhu, Bing Guo, Huaiyu Wang, Litao Sun, Fei Yan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasonics sonochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xin MengDepartment of Ultrasound Medicine, Zhejiang Provincial People's Hospital, Hangzhou Medical College, 310000 Hangzhou, Zhejiang, China; Department of Ultrasound Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou University, 450052 Zhengzhou, China.
Yanan FengDepartment of Ultrasound Medicine, Zhejiang Provincial People's Hospital, Hangzhou Medical College, 310000 Hangzhou, Zhejiang, China.
Yuanyuan WangState Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 518055 Shenzhen, Guangdong, China.
Chen LinDepartment of Ultrasound Medicine, Zhejiang Provincial People's Hospital, Hangzhou Medical College, 310000 Hangzhou, Zhejiang, China.
Wei WangDepartment of Ultrasound Medicine, Zhejiang Provincial People's Hospital, Hangzhou Medical College, 310000 Hangzhou, Zhejiang, China.
Sutian ZhuDepartment of Ultrasound Medicine, Zhejiang Provincial People's Hospital, Hangzhou Medical College, 310000 Hangzhou, Zhejiang, China.
Bing GuoSchool of Science, Shenzhen Key Laboratory of Flexible Printed Electronics Technology, Shenzhen Key Laboratory of Advanced Functional Carbon Materials Research and Comprehensive Application, Harbin Institute of Technology, 518055 Shenzhen, Guangdong, China.
Huaiyu WangCenter for Human Tissues and Organs Degeneration, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 518055 Shenzhen, Guangdong, China.
Litao SunDepartment of Ultrasound Medicine, Zhejiang Provincial People's Hospital, Hangzhou Medical College, 310000 Hangzhou, Zhejiang, China. Electronic address: litaosun1971@sina.com.
Fei YanState Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 518055 Shenzhen, Guangdong, China. Electronic address: fei.yan@siat.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photothermal therapy (PTT) has emerged as a promising new approach in tumor treatment, with the great advantages including non-invasiveness and temporal controllability. However, the effective delivery of photothermal agents into tumor remains a significant challenge, limiting its clinical translational application. In this study, we developed a kind of photothermal agents modified with gas vesicles (GVs), greatly facilitating ultrasound/fluorescence imaging-guided delivery of photothermal agents and enhancing the efficacy of photothermal therapy. The GVs were synthesized and extracted from Halobacterium NRC-1, followed with modification with IR808. The resulting GVs-IR808 were able to be visually tracked by ultrasound and fluorescence imaging. Upon their arrival at the tumor area after systemic administration, ultrasound irradiation was applied to induce the cavitation of GVs-IR808, greatly promoting IR808 delivery into the tumor. The subsequent laser irradiation was applied and resulted in a significant inhibition of tumor growth. In conclusion, our study provides a novel approach for ultrasound/fluorescence dual-modal imaging-guided photothermal treatment of breast tumors.

Indexed as

AcousticsGasesPhotothermal TherapyUltrasonic WavesAnimalsBromine CompoundsCell Line, TumorFemaleHumansIndolesMiceVinyl Compounds1-(5-carboxypentyl)-2-(2-(3-(2-(1-(5-carboxypentyl)-3,3-dimethylindolin-2-ylidene)ethylidene)-2-chlorocyclohex-1-en-1-yl)vinyl)-3,3-dimethyl-3H-indol-1-ium bromideBromine CompoundsGasesIndolesVinyl CompoundsBreast tumorDrug deliveryGas vesiclesIR808Photothermal therapy

Identifiers

PMID40446792
PMCPMC12166705

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.