Evidence map›Paper›PMID 40446587›Full record

ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2025

Dynamic functional connectivity is modulated by the amount of p-Tau231 in blood in cognitively intact participants.

Martín Carrasco-Gómez, Alejandra García-Colomo, Alberto Nebreda, Ricardo Bruña, Andrés Santos, Fernando Maestú

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Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Martín Carrasco-GómezDepartment of Electronic Engineering, ETSIT, Universidad Politécnica de Madrid, Calle Ramiro de Maeztu, 7, 28040 Madrid, Spain; Center for Cognitive and Computational Neuroscience, Complutense University of Madrid, Carretera de Húmera, s/n, 28223 Madrid, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Instituto de Salud Carlos III, Calle Monforte de Lemos, 3-5, 28029 Madrid, Spain. Electronic address: martin.carrasco@upm.es.
Alejandra García-ColomoCenter for Cognitive and Computational Neuroscience, Complutense University of Madrid, Carretera de Húmera, s/n, 28223 Madrid, Spain; Department of Experimental Psychology, Cognitive Psychology and Speech & Language Therapy, Complutense University of Madrid, Carretera de Húmera, s/n, 28223 Madrid, Spain.
Alberto NebredaCenter for Cognitive and Computational Neuroscience, Complutense University of Madrid, Carretera de Húmera, s/n, 28223 Madrid, Spain; Department of Experimental Psychology, Cognitive Psychology and Speech & Language Therapy, Complutense University of Madrid, Carretera de Húmera, s/n, 28223 Madrid, Spain.
Ricardo BruñaCenter for Cognitive and Computational Neuroscience, Complutense University of Madrid, Carretera de Húmera, s/n, 28223 Madrid, Spain; Health Research Institute of the Hospital Clínico San Carlos (IdISSC), Calle Prof. Martín Lagos, s/n, 28240 Madrid, Spain; Department of Radiology, Rehabilitation and Physiotherapy, School of Medicine, Universidad Complutense de Madrid, Plaza de Ramón y Cajal, s/n, 28240 Madrid, Spain.
Andrés SantosDepartment of Electronic Engineering, ETSIT, Universidad Politécnica de Madrid, Calle Ramiro de Maeztu, 7, 28040 Madrid, Spain; CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Instituto de Salud Carlos III, Calle Monforte de Lemos, 3-5, 28029 Madrid, Spain.
Fernando MaestúCenter for Cognitive and Computational Neuroscience, Complutense University of Madrid, Carretera de Húmera, s/n, 28223 Madrid, Spain; Department of Experimental Psychology, Cognitive Psychology and Speech & Language Therapy, Complutense University of Madrid, Carretera de Húmera, s/n, 28223 Madrid, Spain; Health Research Institute of the Hospital Clínico San Carlos (IdISSC), Calle Prof. Martín Lagos, s/n, 28240 Madrid, Spain. Electronic address: fmaestuu@ucm.es.

Funding

Digital biomarker for a low cost ambulatory test for early detection of Alzheimer's diseaseRF1AG074204 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FUNKE, MICHAEL, MOSHER, JOHN COMPTON · 2021 to 2021
$2.1M
NIA NIH HHS RF1 AG074204
6 · The paper itself

Abstract

introductionElectrophysiology and plasma biomarkers are early and non-invasive candidates for Alzheimer's disease detection. The purpose of this paper is to evaluate changes in dynamic functional connectivity measured with magnetoencephalography, associated with the plasma pathology marker p-tau231 in unimpaired adults.

methods73 individuals were included. Static and dynamic functional connectivity were calculated using leakage corrected amplitude envelope correlation. Each source's strength entropy across trials was calculated. A data-driven statistical analysis was performed to find the association between functional connectivity and plasma p-tau231 levels. Regression models were used to assess the influence of other variables over the clusters' connectivity.

resultsFrontotemporal dynamic connectivity positively associated with p-tau231 levels. Linear regression models identified pathological, functional and structural factors that influence dynamic functional connectivity.

conclusionsChanges associated to AD pathology can be observed very early on using dFC, which might be more sensitive to subtle alterations than sFC. Furthermore, this early increase in dFC appears to have a pathological nature given its relationship with other plasma, functional and structural measures. SIGNIFICANCE: These results expand previous literature on dynamic functional connectivity in healthy individuals at risk of AD, highlighting its usefulness as an early, non-invasive and more sensitive biomarker.

Indexed as

BrainCognitiontau ProteinsAdultAgedAlzheimer DiseaseBiomarkersFemaleHumansMagnetoencephalographyMaleMiddle AgedBiomarkerstau ProteinsCognitively intactDynamic functional connectivityEntropyFractional anisotropyMagnetoencephalographyP-tau231Static functional connectivity

Identifiers

PMID40446587
PMCPMC13323520

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.