Evidence map›Paper›PMID 40446468›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2025

Potentiation of group III metabotropic glutamate receptors positively affects neurophysiological features in a mouse model of Rett syndrome.

Hong-Wei Dong, Kelly Weiss, Jonathan W Dickerson, Mac J Meadows, Irene Zagol-Ikapitte, Olivier Boutaud, Jerri M Rook, Jeffrey L Neul, Colleen M Niswender

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hong-Wei DongDivision of Neurology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt University Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Kelly WeissDepartment of Pharmacology, School of Medicine, Vanderbilt University, Nashville, Tennessee; Warren Center for Neuroscience Drug Discovery, School of Medicine, Vanderbilt University, Nashville, Tennessee.
Jonathan W DickersonDepartment of Pharmacology, School of Medicine, Vanderbilt University, Nashville, Tennessee; Warren Center for Neuroscience Drug Discovery, School of Medicine, Vanderbilt University, Nashville, Tennessee.
Mac J MeadowsDepartment of Pharmacology, School of Medicine, Vanderbilt University, Nashville, Tennessee; Warren Center for Neuroscience Drug Discovery, School of Medicine, Vanderbilt University, Nashville, Tennessee.
Irene Zagol-IkapitteDepartment of Pharmacology, School of Medicine, Vanderbilt University, Nashville, Tennessee; Warren Center for Neuroscience Drug Discovery, School of Medicine, Vanderbilt University, Nashville, Tennessee.
Olivier BoutaudDepartment of Pharmacology, School of Medicine, Vanderbilt University, Nashville, Tennessee; Warren Center for Neuroscience Drug Discovery, School of Medicine, Vanderbilt University, Nashville, Tennessee.
Jerri M RookDepartment of Pharmacology, School of Medicine, Vanderbilt University, Nashville, Tennessee; Warren Center for Neuroscience Drug Discovery, School of Medicine, Vanderbilt University, Nashville, Tennessee.
Jeffrey L NeulDivision of Neurology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt University Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Pharmacology, School of Medicine, Vanderbilt University, Nashville, Tennessee; Vanderbilt Brain Institute, Nashville, Tennessee. Electronic address: jeffrey.l.neul@vumc.org.
Colleen M NiswenderVanderbilt University Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Pharmacology, School of Medicine, Vanderbilt University, Nashville, Tennessee; Warren Center for Neuroscience Drug Discovery, School of Medicine, Vanderbilt University, Nashville, Tennessee; Vanderbilt Institute for Chemical Biology, Nashville, Tennessee; Vanderbilt Brain Institute, Nashville, Tennessee. Electronic address: Colleen.Niswender@Vanderbilt.edu.

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
Development of mGlu7 receptor allosteric modulators for neurological and psychiatric disordersR01MH124671 · NIMH · VANDERBILT UNIVERSITY · PI LINDSLEY, CRAIG, NISWENDER, COLLEEN M · 2020 to 2024
$3.5M
NICHD NIH HHS P50 HD103537NIMH NIH HHS R01 MH124671
6 · The paper itself

Abstract

Rett syndrome (RTT) is a neurodevelopmental disorder primarily caused by loss-of-function mutations in the X-linked methyl-CpG-binding protein 2 (MECP2) gene. Genetic restoration of MECP2 in mice can reverse phenotypes, providing hope for disease-modifying therapies in the disease. Studies in people with and mouse models of RTT have identified neurophysiological features, such as auditory event-related potentials (AEPs), that correlate with disease severity, suggesting potential as translatable biomarkers. We have identified reductions in the expression and function of the group III metabotropic glutamate receptor 7 (mGlu

Indexed as

Receptors, Metabotropic GlutamateRett SyndromeAnimalsDisease Models, AnimalEvoked Potentials, AuditoryFemaleHumansMaleMethyl-CpG-Binding Protein 2MiceMice, Inbred C57BLmetabotropic glutamate receptor 3metabotropic glutamate receptor 7Methyl-CpG-Binding Protein 2Receptors, Metabotropic Glutamateauditory event-related potentialmetabotropic glutamate receptor 7mouse modelsneurophysiological biomarkerspositive allosteric modulatorRett syndrome

Identifiers

PMID40446468
PMCPMC12264540

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.