ArticleACS chemical neuroscience2025
Microinvasive Probes for Monitoring Electrical and Chemical Neural Activity in Nonhuman Primates.
Article in ACS chemical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Striatal dopamine signals internal states related to behavioral performance over prolonged timescales in monkeys.bioRxiv : the preprint server for biology · 2026Article
- Flexible Polymer-Based Electronics for Human Health Monitoring: A Safety-Level-Oriented Review of Materials and Applications.Nano-micro letters · 2026Review
- Aseptic, semi-sealed cranial chamber implants for chronic multi-channel neurochemical and electrophysiological neural recording in nonhuman primates.Journal of neuroscience methods · 2025Article
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Authors and funding
8 authors.
Funding
Abstract
We leveraged carbon fiber materials for creating sensors that provide dual neurochemical and electrical neural activity recording at microinvasive (10 μm) spatial footprints proximal to recording sites, and enabling these measurements from deep brain targets of primates with conventional cranial chambers. These shaft-assisted microinvasive probes (s-μIPs) are approximately 10 μm in diameter along the distal length (1-15 mm) immediately surrounding the targeted recording site. This microinvasive portion ensures that the recording site is isolated from tissue damage induced by the wider shaft portion of the device. The shaft (150-165 μm in diameter) within the device stiffens the remaining length of the probe (>100 mm), and provides compatibility with standard intracranial insertion protocols (e.g., guide tubes and chamber setups) that require a sufficiently rigid and long shaft for deep brain insertion in monkeys. The s-μIP was further expanded to provide dual-channel chemical and electrical neural activity recording with micrometer spatial resolution. Measurements of reward- and movement- related dopamine, spikes, and local field potentials were made from single and dual-channel s-μIPs implanted in task-performing monkeys. Recordings from chronically implanted s-μIPs display the capability of functional multimodal (chemical and electrical) neural activity measurements over 1-year postimplantation from microinvasive devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.