Evidence map›Paper›PMID 40446018›Full record

ArticleScience immunology2025

An activating

Rachael L Philips, Yi-Chu Liao, Colleen M Lau, Tasha A Morrison, Kan Jiang, Amal Hutchinson, Justin Shayne, Chen Yao, Joseph C Sun, Heather D Hickman and 5 more

Abstract read
In one paragraph

Article in Science immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rachael L PhilipsLymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch (MIIB), National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD 20892, USA.ORCID 0000-0001-5440-4594
Yi-Chu LiaoLymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch (MIIB), National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD 20892, USA.ORCID 0000-0002-9458-1445
Colleen M LauDepartment of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA.ORCID 0000-0001-7538-094X
Tasha A MorrisonLymphocyte Signaling Unit, MIIB, NIAMS, Bethesda, MD 20892, USA.ORCID 0000-0002-6403-9364
Kan JiangBiodata Mining and Discovery Section, NIAMS, Bethesda, MD 20892, USA.ORCID 0000-0001-9065-4574
Amal HutchinsonLymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch (MIIB), National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD 20892, USA.
Justin ShayneLymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch (MIIB), National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD 20892, USA.ORCID 0009-0003-5617-6494
Chen YaoLymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch (MIIB), National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD 20892, USA.ORCID 0000-0001-6852-5661
Joseph C SunImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.ORCID 0000-0001-8062-9033
Heather D HickmanViral Immunity and Pathogenesis Unit, Laboratory of Clinical Immunology and Microbiology (LCIM), NIAID, Bethesda, MD 20892, USA.ORCID 0000-0003-4168-4894
Joshua D MilnerDivision of Pediatric Allergy Immunology and Rheumatology, Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, USA.
Steve HollandImmunopathogenesis Section, LCIM, NIAID, Bethesda, MD 20892, USA.ORCID 0000-0003-3207-5464
Yuka KannoLymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch (MIIB), National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD 20892, USA.ORCID 0000-0001-5668-9319
Michail S LionakisFungal Pathogenesis Section, LCIM, NIAID, Bethesda, MD 20892, USA.ORCID 0000-0003-4994-9500
John J O'SheaLymphocyte Cell Biology Section, Molecular Immunology and Inflammation Branch (MIIB), National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD 20892, USA.ORCID 0000-0002-6456-9752

Funding

Targeting Jak3 in the treatment of autoimmune diseaseZ01AR041106 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI O'SHEA, JOHN J. · 1995 to 2008
$2.7M
Genomic regulation of immune response by a STAT1 gain of function mutationR00AI177758 · NIAID · OHIO STATE UNIVERSITY · PI Rachael Laura Philips · 2026 to 2026
$249k
Consequences of a Stat1 gain-of-function mutation in gene expression and viral responseFI2GM137942 · NIGMS · NATIONAL INST ARTH/MUSCLOSKEL/SKIN DIS · PI PHILIPS, RACHAEL LAURA · 2020 to 2020
–
Intramural NIH HHS Z01 AR041106NIAID NIH HHS K99 AI177758NIAID NIH HHS R00 AI177758NIGMS NIH HHS FI2 GM137942
6 · The paper itself

Abstract

Interferonopathies drive autoimmunity but can also impair host responses to pathogens, including viral infections. To better understand viral susceptibility of patients with

Indexed as

Immunity, InnateLymphocytesSTAT1 Transcription FactorSTAT4 Transcription FactorAnimalsGain of Function MutationInterferon-gammaLymphocytic choriomeningitis virusMiceMice, Inbred C57BLInterferon-gammaStat1 protein, mouseSTAT1 Transcription FactorStat4 protein, mouseSTAT4 Transcription Factor

Identifiers

PMID40446018
PMCPMC13316826

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.