Evidence map›Paper›PMID 40445729›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

A Novel Function of Na

Léa Réthoré, Anne-Laure Guihot, Linda Grimaud, Coralyne Proux, Benjamin Barré, François Guillonneau, Catherine Guette, Alice Boissard, Cécile Henry, Jérôme Cayon and 4 more

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Léa RéthoréINSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, Univ Angers, Angers, France.
Anne-Laure GuihotINSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, Univ Angers, Angers, France.
Linda GrimaudINSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, Univ Angers, Angers, France.
Coralyne ProuxINSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, Univ Angers, Angers, France.
Benjamin BarréUniv Angers, Angers, France.
François GuillonneauInstitut de Cancérologie de l'Ouest (ICO), Angers, France.
Catherine GuetteInstitut de Cancérologie de l'Ouest (ICO), Angers, France.
Alice BoissardInstitut de Cancérologie de l'Ouest (ICO), Angers, France.
Cécile HenryInstitut de Cancérologie de l'Ouest (ICO), Angers, France.
Jérôme CayonSFR ICAT, PACeM (Plateforme d'Analyse Cellulaire et Moléculaire), Univ Angers, Angers, France.
Rodolphe PerrotSFR ICAT, SCIAM (Service Commun d'Imageries et d'Analyses Microscopiques), Univ Angers, Angers, France.
Daniel HenrionINSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, Univ Angers, Angers, France.
Christian LegrosINSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, Univ Angers, Angers, France.ORCID https://orcid.org/0000-0002-3346-7059
Claire LegendreINSERM, CNRS, MITOVASC, Equipe CarME, SFR ICAT, Univ Angers, Angers, France.ORCID https://orcid.org/0000-0003-0248-1111

Funding

Fondation Banque Populaire Grand OuestFondation pour la Recherche Médicale (FRM) FDT202204014720
6 · The paper itself

Abstract

Endothelial cells (EC) play a pivotal role in vascular homeostasis. By sensing shear stress generated by blood flow, EC endorse vasculoprotection through mechanotransduction signaling pathways. Various ion channels are involved in mechanosignaling, and here, we investigated the endothelial voltage-gated Na

Indexed as

AutophagyEndothelial CellsCells, CulturedHumansHuman Umbilical Vein Endothelial CellsKruppel-Like Factor 4Kruppel-Like Transcription FactorsMechanotransduction, CellularNAV1.5 Voltage-Gated Sodium ChannelSignal TransductionStress, MechanicalKLF2 protein, humanKLF4 protein, humanKruppel-Like Factor 4Kruppel-Like Transcription FactorsNAV1.5 Voltage-Gated Sodium ChannelSCN5A protein, humanautophagyendothelial cellmechanosignalingNaVβ3SCN3Bshear stress

Identifiers

PMID40445729
PMCPMC12124425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.