Evidence map›Paper›PMID 40445560›Full record

GuidelineClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2025

SEOM-GEMCAD-TTD clinical guidelines for biliary tract cancer (2025).

Teresa Macarulla, Jorge Adeva, Maria Teresa Cano Osuna, Ana Ruiz Casado, Ana María Jiménez Gordo, Angela Lamarca, Ana María López Muñoz, Roberto Antonio Pazo Cid, Tamara Saurí, Javier Gallego Plazas

Abstract readPractice GuidelineSystematic Review
In one paragraph

Guideline in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. SEOM-GEMCAD-TTD clinical guideline for the diagnosis and treatment of esophageal cancer (update 2025).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Guideline
  2. Trial
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Teresa MacarullaMedical Oncology Department, Hospital Universitario Vall D'Hebron, Barcelona, Spain. tmacarulla@vhio.net.ORCID http://orcid.org/0000-0002-1881-362X
Jorge AdevaMedical Oncology Department, Hospital Universitario, 12 de Octubre, Madrid, Spain.
Maria Teresa Cano OsunaMedical Oncology Department, Hospital Universitario Reina Sofía, Córdoba, Spain.
Ana Ruiz CasadoMedical Oncology Department, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.
Ana María Jiménez GordoMedical Oncology Department, Hospital Universitario Infanta Sofía, Madrid, Spain.
Angela LamarcaMedical Oncology Department, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain.
Ana María López MuñozMedical Oncology Department, Hospital Universitario de Burgos, Burgos, Spain.
Roberto Antonio Pazo CidMedical Oncology Department, Hospital Universitario Miguel Servet, Saragossa, Spain.
Tamara SauríMedical Oncology Department, Hospital Clínic, Barcelona, Spain.
Javier Gallego PlazasMedical Oncology Department, Hospital General Universitario de Elche, Alicante, Spain. j.gallegoplazas@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biliary tract cancers (BTC) are aggressive and fatal. Early recognition of symptoms and proper diagnostic work up allow for precise histopathological and molecular classification as well as accurate evaluation of the extent of disease. Surgery is the only potentially curative therapy in localized stages; however, disease recurrence is common and adjuvant chemotherapy appears to improve survival. Upfront systemic chemotherapy with immunotherapy is the treatment of choice in unresectable locally-advanced and metastatic disease. Inroads made in understanding its molecular biology has enabled new therapeutic targets to be identified with current indications and encouraging results that could further improve BTC patients' survival and quality of life.

Indexed as

Biliary Tract NeoplasmsChemotherapy, AdjuvantDeoxycytidineGemcitabineHumansImmunotherapyDeoxycytidineGemcitabineBiliary tract cancerCholangiocarcinomaDiagnosisPrecision medicineTreatment

Identifiers

PMID40445560
PMCPMC12259768

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.