The Influence of Autophagy-Modulating Drugs on the Expression of Markers Associated with Cancer-Associated Fibroblasts and Epithelial-Mesenchymal Transition in a Mouse Model of Skin Melanoma.

Iu S Taskaeva, A Yu Shatruk, N P Bgatova

Abstract read

In one paragraph

Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

3 authors.

Iu S TaskaevaResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia. inabrite@yandex.ru.

A Yu ShatrukResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

N P BgatovaResearch Institute of Clinical and Experimental Lymphology - Branch of Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The expression of cancer-associated fibroblast (CAF) and epithelial-mesenchymal transition marker proteins was assessed in tumor samples of B16 skin melanoma-bearing mice after chloroquine or lithium administration. Chloroquine increased the expression of CAF markers (αSMA and FAP). Hence, chloroquine can contribute to the activation of individual CAF populations in melanoma. In addition, a decrease in the expression of the epithelial marker E-cadherin and an increase in the expression of the mesenchymal marker vimentin were observed after chloroquine administration, which may indicate activation of epithelial-mesenchymal transition processes in the tumor.

Indexed as

AutophagyCancer-Associated FibroblastsChloroquineEpithelial-Mesenchymal TransitionMelanoma, ExperimentalSkin NeoplasmsActinsAnimalsCadherinsDisease Models, AnimalEndopeptidasesFibroblast Activation Protein AlphaGene Expression Regulation, NeoplasticMembrane ProteinsMiceMice, Inbred C57BLActinsCadherinsChloroquineEndopeptidasesFibroblast Activation Protein AlphaMembrane ProteinsVimentinautophagycancer-associated fibroblastschloroquineepithelial–mesenchymal transitionskin melanoma

Identifiers

PMID40445543

DOI10.3390/ijms22105283

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.