Evidence map›Paper›PMID 40445541›Full record

ArticleBulletin of experimental biology and medicine2025

Differences in the Blood Levels of HIF-1α and VNN1 and Expression of HIF1A and NFKB1 in Leukocytes in Cardiological Patients with Risk of Postoperative Complications.

M V Silina, D Sh Dzhalilova, M A Diatroptova, O O Grin, M A Babaev, O V Makarova

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Predictive Value of PreoperativeInternational journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

M V SilinaPetrovsky National Research Centre of Surgery, Moscow, Russia. marusyasilina99@yandex.ru.
D Sh DzhalilovaPetrovsky National Research Centre of Surgery, Moscow, Russia.
M A DiatroptovaPetrovsky National Research Centre of Surgery, Moscow, Russia.
O O GrinPetrovsky National Research Centre of Surgery, Moscow, Russia.
M A BabaevPetrovsky National Research Centre of Surgery, Moscow, Russia.
O V MakarovaPetrovsky National Research Centre of Surgery, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The systemic inflammatory response that develops after cardiac surgery with the use of cardiopulmonary bypass, has individual features of its course, and perioperative assessment of its activity can serve as a basis for the development of a personalized approach to predicting the development and severity of the course of postoperative complications. We found that patients with high risk of postoperative infectious and inflammatory complications are characterized by high blood levels of HIF-1α and VNN1 proteins before surgery, as well as 24 and 72 h after it, and high level of HIF1A expression in leukocytes 72 h after surgery. The obtained data are necessary for understanding the individual features of the course of the systemic inflammatory response that develops after surgical interventions, as well as for timely treatment of organ dysfunctions during intensive care.

Indexed as

Hypoxia-Inducible Factor 1, alpha SubunitLeukocytesNF-kappa B p50 SubunitPostoperative ComplicationsAgedCardiac Surgical ProceduresCardiopulmonary BypassFemaleHumansInflammationMaleMiddle AgedHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitNF-kappa B p50 SubunitNFKB1 protein, humanbiomarkersHIFhypoxiainflammationvanin

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.