Evidence map›Paper›PMID 40445538›Full record

ArticleBulletin of experimental biology and medicine2025

The Influence of Homoarginine and β-Aminoisobutyric Acid on Migration and Proliferation of Smooth Muscle Cells of Rat Aorta.

D A Tanyanskiy, A Yu Kotov, A V Demyanov, A B Malashicheva, P M Docshin, I V Kudriavtsev

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

D A TanyanskiyInstitute of Experimental Medicine, St. Petersburg, Russia. dmitry.athero@gmail.com.
A Yu KotovState Research Institute of Highly Pure Biopreparations, Federal Medical-Biological Agency of Russia, St. Petersburg, Russia.
A V DemyanovInstitute of Experimental Medicine, St. Petersburg, Russia.
A B MalashichevaInstitute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.
P M DocshinInstitute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia.
I V KudriavtsevInstitute of Experimental Medicine, St. Petersburg, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-protein amino acids homoarginine (hArg) and β-aminoisobutyric acid (BAIBA) inhibit atherogenesis by weakening the inflammatory response in the vascular wall. The influence of these amino acids on growth factor-induced migration and proliferation of smooth muscle cells (SMC) of rat aorta was studied in vitro. It was found that hArg and BAIBA did not affect these processes, though the latter were suppressed by NO. Thus, hArg and BAIBA do not directly affect the migration and proliferation of aortic SMC, but can affect these processes indirectly through hArg modulation of NO production by endothelial cells, and, probably, due to the anti-inflammatory properties of these amino acids.

Indexed as

Aminoisobutyric AcidsAortaCell MovementHomoarginineMyocytes, Smooth MuscleAnimalsCell ProliferationCells, CulturedMaleMuscle, Smooth, VascularNitric OxideRatsRats, Wistar2-aminoisobutyric acid3-aminoisobutyric acidAminoisobutyric AcidsHomoarginineNitric Oxideatherosclerosishomoargininenon-protein amino acidssmooth muscle cellsβ-aminoisobutyric acid

Identifiers

PMID40445538

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.