Evidence map›Paper›PMID 40445537›Full record

ArticleBulletin of experimental biology and medicine2025

Modeling of Frequency Dependence of Selectivity and Sensitivity of Mammalian Otolith Membranes during Electrical Stimulation of the Vestibular Nerves.

V V Udut, V P Demkin, S V Melnichuk, T V Rudenko, M V Svetlik, M D Akinina, O V Demkin, L V Smaglii, V M Alifirova, O V Grebenuk

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

V V UdutNational Research Tomsk State University, Tomsk, Russia.
V P DemkinNational Research Tomsk State University, Tomsk, Russia.
S V MelnichukNational Research Tomsk State University, Tomsk, Russia.
T V RudenkoNational Research Tomsk State University, Tomsk, Russia. rudenko@ido.tsu.ru.
M V SvetlikNational Research Tomsk State University, Tomsk, Russia.
M D AkininaNational Research Tomsk State University, Tomsk, Russia.
O V DemkinNational Research Tomsk State University, Tomsk, Russia.
L V SmagliiNational Research Tomsk State University, Tomsk, Russia.
V M AlifirovaSiberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
O V GrebenukNational Research Tomsk State University, Tomsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A numerical experiment was conducted to determine the spectral sensitivity and selectivity of the cellular components of the utricle and saccule of a laboratory animal (rat) to a periodic electrical stimulation. Equivalent electrical circuit of otolith replacement was used. Its parameters were determined from the anatomical structure and from the measured specific characteristics of cellular elements taking into account the changing ionic conductivity. It was found that the frequency dependence of the impedance and the spectral sensitivity of the cell elements for the utricle and saccule have a resonant nature. The obtained data about the mechanisms of electrical stimulation of hair cells, their spectral sensitivity, and frequency selectivity can serve as the basis for choosing the optimal mode of electrical stimulation in a vestibular implant.

Indexed as

Otolithic MembraneSaccule and UtricleVestibular NerveAnimalsElectric StimulationHair Cells, VestibularRatselectrical stimulationequivalent electrical circuitfrequency selectivityotolith organsspectral sensitivity

Identifiers

PMID40445537

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.