Evidence map›Paper›PMID 40445536›Full record

ArticleBulletin of experimental biology and medicine2025

Tumor Proteolytic Activity in Esophageal Cancer.

E I Goufman, N B Tikhonova, K B Gershkovich, A P Aleksankin, A A Stepanov, N V Nizyaeva, V V Bochkov, L M Mikhaleva, O V Kovaleva, I S Stilidi and 1 more

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

E I GoufmanPetrovsky National Research Centre of Surgery, Moscow, Russia. eugene_goufman@mail.ru.
N B TikhonovaPetrovsky National Research Centre of Surgery, Moscow, Russia.
K B GershkovichEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russia.
A P AleksankinPetrovsky National Research Centre of Surgery, Moscow, Russia.
A A StepanovPetrovsky National Research Centre of Surgery, Moscow, Russia.
N V NizyaevaPetrovsky National Research Centre of Surgery, Moscow, Russia.
V V BochkovPetrovsky National Research Centre of Surgery, Moscow, Russia.
L M MikhalevaPetrovsky National Research Centre of Surgery, Moscow, Russia.
O V KovalevaN. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
I S StilidiN. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.
N E KushlinskiiN. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The growth of malignant tumors is accompanied by an increase in plasmin activity, one of the key enzymes in oncogenesis. IgG proteolysis by plasmin yields fragments with exposed C-terminal lysine residues that can bind to plasmin heavy chain. Highly purified plasminogen (plasmin precursor) and heavy chains containing lysine-binding sites were isolated. The formation of IgG fragments as a result of their proteolysis by plasmin in solution was shown. Using ELISA with immobilized heavy chains, we found increased concentration of IgG fragments in the sera of patients with esophageal cancer in comparison with healthy donors. The test had high sensitivity (91%) and specificity (85%).

Indexed as

Esophageal NeoplasmsFibrinolysinImmunoglobulin GAgedEnzyme-Linked Immunosorbent AssayFemaleHumansMaleMiddle AgedPlasminogenProteolysisFibrinolysinImmunoglobulin GPlasminogenenzyme-linked immunoassayesophageal carcinomaIgG degradation productstumor proteolytic activity

Identifiers

PMID40445536

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.