SynthesisEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2025
β-lactam antibiotics vs vancomycin in treating methicillin-sensitive staphylococcus aureus bloodstream infections: a meta-analysis of clinical outcomes.
Synthesis in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- ASP-COMPLEX: redefining antimicrobial stewardship to improve outcomes in high-risk patients with severe infections.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026Review
- Fatal Catheter-Related Hematogenous Disseminated MSSA Sepsis in an Immunocompromised Lung Cancer Patient: A Case Report.Infection and drug resistance · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis meta-analysis systematically reviews and compares the efficacy of β-lactam antibiotics and vancomycin in the treatment of methicillin-sensitive Staphylococcus aureus (MSSA) bloodstream infections, with the aim of providing evidence-based recommendations for clinical decision-making.
methodsThis systematic review and meta-analysis followed the PRISMA 2020 guidelines and was registered with PROSPERO. Two independent reviewers conducted comprehensive literature searches across multiple databases, specifically targeting Randomized Controlled Trial (RCT) and non-RCT comparing β-lactam antibiotics and vancomycin in treating MSSA bloodstream infections. Outcomes analyzed included mortality within 30 days and 90 days, defervescence time, bacterial clearance time, and treatment duration.
resultsSeven retrospective cohort studies involving a total of 6957 patients were included. The pooled results indicated no significant difference in 30-day and 90-day mortality or treatment duration between the two antibiotics regimens. However, β-lactam antibiotics demonstrated a faster action, with significantly shorter times for fever reduction and bacterial clearance compared to vancomycin.
conclusionsThis study found that β-lactam antibiotics are more efficacious than vancomycin in treating MSSA bloodstream infections. Although clinical outcomes such as mortality and treatment duration were similar between the groups, the faster clinical response observed with β-lactam antibiotics supports their preferential use in cases of MSSA infection. Since all included studies were retrospective, the overall reliability of the evidence is affected. Future high-quality prospective studies are needed to further validate these findings.
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Registered trials
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