ArticleOphthalmology and therapy2025
Transepithelial Versus Conventional PRK: A Randomized Controlled Study.
Article in Ophthalmology and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04698174 (Prospective Clinical Study to Evaluate the Safety and Efficacy of a New Transepithelial Photorefractive Keratectomy Treatment), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Clinical Study to Evaluate the Safety and Efficacy of a New Transepithelial Photorefractive Keratectomy Treatment
Who cites it
2 citing papers in PubMed.
- Short-term OCT-based evaluation of corneal epithelial remodeling with two silicone hydrogel bandage contact lenses after t-PRK.International ophthalmology · 2026Trial
- Comparative clinical outcomes of SMILE, femtosecond LASIK, and transepithelial PRK: a multicenter Iraqi study.Frontiers in ophthalmology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTransepithelial photorefractive keratectomy (t-PRK) is an updated maneuver based on the proven surgical procedure of conventional photorefractive keratectomy (PRK) for the correction of ametropia. Unlike conventional PRK, which is a two-step process involving the physical removal of the corneal epithelium prior to excimer laser treatment of the stroma, t-PRK uses the excimer laser to complete both activities in a single-step procedure.
methodsThis was a prospective, randomized, controlled, contralateral, masked, single-surgeon study of adult subjects with myopia with a manifest residual spherical equivalent (MRSE) of ≤ 1.5 D or hyperopia with an MRSE of ≥ + 1.5 D, conducted at a single center in the Philippines. Eligible subjects were randomized to undergo conventional PRK in one eye and t-PRK in the other. The follow-up was for 6 months. The primary endpoint evaluated the absolute refractive predictability at 3 months. Secondary endpoints during the 6-month follow-up included safety, manifest refraction, visual acuity, halos and glare, slit-lamp examinations, and patient-reported outcomes.
resultsA total of 35 subjects (70 eyes) were enrolled (63% female, 94% Asian, mean age 30 years). The mean (standard deviation [SD]) absolute prediction error was 0.26 D (0.23) for conventional PRK and 0.34 D (0.32) for t-PRK, meeting the threshold for demonstration of noninferiority (p = 0.2253). There were no statistically significant differences between conventional PRK and t-PRK for manifest sphere, manifest cylinder, MRSE, or uncorrected or corrected visual acuity at 6 months. All subjects were satisfied with both procedures and there was no preference for one treatment over the other.
conclusionsBoth conventional and t-PRK are equally safe and effective, and result in favorable outcomes for subjects with ametropia. The efficiency of the t-PRK procedure versus conventional PRK should be considered when PRK is indicated.
trial registrationClinicalTrials.gov, NCT04698174.
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