Evidence map›Paper›PMID 40445498›Full record

ArticleEJNMMI radiopharmacy and chemistry2025

Selection of the optimal chelator for labeling of DARPin Ec1 with gallium-68 for PET imaging of EpCAM expression.

Anzhelika Vorobyeva, Moeen-Ud Din, Alexey Schulga, Elena Konovalova, Ayman Abouzayed, Olga Bragina, Ruonan Li, Torbjörn Gräslund, Sergey M Deyev, Maryam Oroujeni

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Article in EJNMMI radiopharmacy and chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Anzhelika VorobyevaDepartment of Immunology, Genetics and Pathology, Uppsala University, 751 85, Uppsala, Sweden.
Moeen-Ud DinDepartment of Immunology, Genetics and Pathology, Uppsala University, 751 85, Uppsala, Sweden.
Alexey SchulgaMolecular Immunology Laboratory, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia.
Elena KonovalovaMolecular Immunology Laboratory, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia.
Ayman AbouzayedDepartment of Medicinal Chemistry, Uppsala University, 75183, Uppsala, Sweden.
Olga BraginaDepartment of Nuclear Medicine, Cancer Research Institute, Tomsk National Research Medical Center Russian Academy of Sciences, 634050, Tomsk, Russia.
Ruonan LiDepartment of Protein Science, KTH Royal Institute of Technology, 10691, Stockholm, Sweden.
Torbjörn GräslundDepartment of Protein Science, KTH Royal Institute of Technology, 10691, Stockholm, Sweden.
Sergey M DeyevMolecular Immunology Laboratory, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997, Moscow, Russia.
Maryam OroujeniDepartment of Immunology, Genetics and Pathology, Uppsala University, 751 85, Uppsala, Sweden. maryam.oroujeni@igp.uu.se.ORCID http://orcid.org/0000-0003-2660-9837

Funding

Cancerfonden 20 0893 PjCancerfonden 23 0650 JIACancerfonden 24 3883 PjSvenska Sällskapet för Medicinsk Forskning 815200-8317Uppsala Universitet UFV-PA 2022/3323Vetenskapsrådet 2022-01519
6 · The paper itself

Abstract

backgroundEpithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein, which is overexpressed in several types of malignancies. Designed ankyrin repeat protein (DARPin) Ec1 is a 19 kDa engineered scaffold protein that binds with high affinity to EpCAM. Radiolabelled Ec1 might be used as a companion diagnostic for the selection of patients for personalized therapy. This study aimed to investigate the influence of different radiometal-chelator complexes on the biodistribution and imaging contrast of

resultsAll Ec1 variants were successfully labelled with

conclusion[

Indexed as

68GaDesigned ankyrin repeat proteins (DARPin)Epithelial cell adhesion molecule (EpCAM)PET imagingSKOV-3 xenograft

Identifiers

PMID40445498
PMCPMC12125460

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