Evidence map›Paper›PMID 40445486›Full record

ArticleIrish journal of medical science2025

Macrophage migration inhibitory factor (rs755622) gene polymorphism in vitiligo.

Doaa Falih Hadi, Abdel-Aziz Ibrahim El-Taweel, Amany Ibrahim Mustafa, Ola Samir El-Shimi, Mahmoud A Rageh

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Article in Irish journal of medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Doaa Falih HadiDepartment of Dermatology, Faculty of Medicine, Benha University, Benha, Egypt.
Abdel-Aziz Ibrahim El-TaweelDepartment of Dermatology, Faculty of Medicine, Benha University, Benha, Egypt.
Amany Ibrahim MustafaDepartment of Dermatology, Faculty of Medicine, Benha University, Benha, Egypt.
Ola Samir El-ShimiDepartment of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Benha, Egypt.
Mahmoud A RagehDepartment of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. dr.mahmoudrageh@gmail.com.ORCID http://orcid.org/0000-0001-6212-9748

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitiligo is a cutaneous disease caused by the destruction of functioning melanocytes. Cellular immunity is known to have a role in the pathogenesis of vitiligo. Macrophage migration inhibitory factor (MIF) is a potent activator of macrophages and is considered to play an important role in cell-mediated immunity.

aimsWe tried to investigate the association between MIF (rs755622) gene polymorphism and vitiligo susceptibility and its relationship to severity and clinical types of the disease.

methodsFifty patients with vitiligo and 50 healthy controls were included. Determination of MIF gene (rs755622) single nucleotide polymorphism was conducted using polymerase chain reaction (PCR).

resultsThere were 18 males and 32 females who had vitiligo, together with 50 control participants of matched age and gender. Taking GG genotype and G allele as references, MIF GC, CC, (GC + CC) genotypes, and C allele demonstrated a substantially higher occurrence in all patients when compared to controls, with a higher risk of developing vitiligo within healthy control subjects.

conclusionsTo the best of our knowledge, this is the third study worldwide and the first from Egypt to investigate the association between MIF gene polymorphism (rs755622) with vitiligo susceptibility and severity, and it showed that MIF gene polymorphism (rs755622) may be considered a risk factor for vitiligo susceptibility. Moreover, it may be associated with higher disease extent.

Indexed as

Intramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsPolymorphism, Single NucleotideVitiligoAdultCase-Control StudiesEgyptFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedYoung AdultIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMIF protein, humanAutoimmune diseasesMacrophage migration inhibitory factorPolymorphism geneticsVitiligo

Identifiers

PMID40445486
PMCPMC12276111

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