ReviewStress biology2025
The synthesis, degradation and biological function of trehalose- 6-phosphate.
Review in Stress biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
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Who cites it
10 citing papers in PubMed.
- Trehalose-6-Phosphate Phosphatase I (TPPI) Regulates Floral Transition, Nitrogen Responses, and Photosynthetic Performance in Arabidopsis.Plants (Basel, Switzerland) · 2026Article
- Dynamics of Gene and Allelic Expression During Modern Hybrid Maize Breeding.Plant biotechnology journal · 2026Article
- Ultra-rapid and high-titer biomanufacturing of trehalose 6-phosphate by an in vitro synthetic biology platform.Bioresources and bioprocessing · 2026Article
- CcAbl1 is required for virulence via regulating NADPH-glutathione-mediated redox balance in Cytospora chrysosperma.Stress biology · 2026Article
- Article
- Trehalulose serves as a distinctive marker for Indonesian stingless bee honey under raw and dehumidified conditions.Scientific reports · 2026Article
- Distinct Roles of Two UDP-N-Acetylglucosamine Pyrophosphorylase Genes in Chitin Biosynthesis and Molting ofInsects · 2026Article
- Plant growth promoting rhizobacteria (PGPR) mediated amelioration of plant tolerance to abiotic stresses: Drought, salinity, and heavy metals.Archives of microbiology · 2026Review
- Trehalose metabolism: an integrative hub linking energy homeostasis and development in insects.Frontiers in insect science · 2026Review
- From heat stress to recovery: proteomic insights into endangered Brachymystax tsinlingensis survival strategies and the ameliorative effects of anti-stress additives.Stress biology · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Trehalose-6-phosphate (T6P), an intermediate in trehalose metabolic pathways, is ubiquitously present in nearly all cellular organisms except vertebrates. The most well-characterized metabolic route involves its synthesis by trehalose-6-phosphate synthase (TPS) and dephosphorylation to trehalose by trehalose-6-phosphate phosphatase (TPP) in the TPS/TPP pathway. Besides, alternative trehalose metabolic pathways aslo exist. In addition to being the precursor of trehalose synthesis, T6P functions as a signal molecule regulating various biological processes. In plants, T6P inhibits SnRK1 (Sucrose-nonfermenting 1 Related Kinase 1), while in fungi, T6P primarily inhibits hexokinase and regulates glycolysis. Notably, TPS and TPP themselves also have some regulatory functions. Genetic studies reveal that deletion of TPS or TPP usually causes developmental and virulence defects in fungi, bacteria and invertebrates. Given that TPS and TPP have important biological functions in pathogenic fungi but are absent in humans and vertebrates, they are ideal targets for fungicide development. This review summarizes trehalose metabolic pathways and the multifaceted roles of T6P in plants, fungi and invertebrates, providing a comprehensive overview of its biological functions. Additionally, it discusses some reported TPS/TPP inhibitor to offer insights for pathogen control strategies.
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Registered trials
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