ArticleDiscover oncology2025
Causal association between periodontitis and oral cancer: a two-sample Mendelian randomization study.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- The Silent Link: Exploring the Impact of Periodontal Diseases on Head and Neck Carcinogenesis.Clinical and experimental dental research · 2026Review
- Periodontal Disease and Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis of Risk and Survival Outcomes.Journal of clinical medicine · 2026Review
- Relationship between periodontitis and oral cancer: A Mendelian randomization study.Bioinformation · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectivesReports suggest an association between periodontitis and oral cancer. Therefore, this study used a Mendelian randomisation analysis to investigate whether a causal relationship exists between periodontitis and oral cancer and whether periodontitis is a reliable early indicator of oral cancer.
methodsPublicly available genome-wide association study data of a European population were used to perform a two-sample, two-way Mendelian randomisation (MR) analysis primarily via inverse variance weighting (IVW). Complementary methods were used to detect and correct the effects of horizontal pleiotropy.
resultsAcute periodontitis (IVW [odds ratio (OR) = 0.999, 95% confidence interval (CI) = 0.999-1.000, P = 0.972]; MR-Egger [OR = 1.000, 95% CI = 0.999-1.000, P = 0.843]; and weighted median [OR = 1.000, 95%CI = 0.999-1.000, P = 0.947]) and chronic periodontitis (IVW [OR = 0.999, 95% CI = 0.999 -1.000, P = 0.725; MR-Egger [OR = 1.000, 95% CI = 0.998-1.000, P = 0.245); and weighted median [OR = 1.000, 95% CI = 0.999-1.000, P = 0.834]) did not affect oral cancer.
conclusionsOur MR analysis did not support a causal relationship between periodontitis and oral cancer. Preventing and treating acute or chronic periodontitis may not reduce the oral cancer risk, and the advantages of screening patients for periodontitis for early cancer detection are limited, which may provide assistance in reducing clinical inputs. This study bears some limitations including inapplicable method if the relationship is non-linear. Analyzing statistical data in a database stratified by sex or age is difficult, potentially leading to biased results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.