Evidence map›Paper›PMID 40445364›Full record

Observational studyEuropean journal of nutrition2025

Triglycerides-Total Cholesterol-Body Weight Index, bone metabolism indicators and bone mineral density in Chinese children: a mediation analysis.

Xueyi Jin, Xueqian Mao, Ying Hu, Jinli Mahe, Kai Guo, Xiaoming Liu, Xuejiao Zeng, Zifu Zhao, Jingyu Hao, Yuming Chen and 2 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xueyi JinDepartment of Epidemiology and Statistics, School of Public Health, Lanzhou University, 222 Tianshui South Road, Lanzhou, Gansu Province, 730000, China.
Xueqian MaoDepartment of Epidemiology and Statistics, School of Public Health, Lanzhou University, 222 Tianshui South Road, Lanzhou, Gansu Province, 730000, China.
Ying HuDepartment of Epidemiology and Statistics, School of Public Health, Lanzhou University, 222 Tianshui South Road, Lanzhou, Gansu Province, 730000, China.
Jinli MaheThe School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Kai GuoInstitute of Health Statistics, School of Public Health, Baotou Medical College Inner Mongolia University of Science and Technology, Baotou, 014040, China.
Xiaoming LiuDepartment of Epidemiology and Statistics, School of Public Health, Lanzhou University, 222 Tianshui South Road, Lanzhou, Gansu Province, 730000, China.
Xuejiao ZengDepartment of Epidemiology and Statistics, School of Public Health, Lanzhou University, 222 Tianshui South Road, Lanzhou, Gansu Province, 730000, China.
Zifu ZhaoInner Mongolia Yili Industrial Group Co., Ltd., Hohhot, 010110, China.
Jingyu HaoInner Mongolia Yili Industrial Group Co., Ltd., Hohhot, 010110, China.
Yuming ChenDepartment of Epidemiology, School of Public Health, Sun Yet-sen University, Guangzhou, 510080, China.
Gexiang ZhangDepartment of Nutrition and Food Hygiene, School of Public Health, Lanzhou University, Lanzhou, Gansu Province, China.
Lipeng JingDepartment of Epidemiology and Statistics, School of Public Health, Lanzhou University, 222 Tianshui South Road, Lanzhou, Gansu Province, 730000, China. jinglp@lzu.edu.cn.

Funding

Fundamental Research Funds for the Central Universities lzujbky-2023-40
6 · The paper itself

Abstract

purposeThis study aimed to investigate the correlation between the Triglycerides × Total Cholesterol × Body Weight Index (TCBI) and bone mineral density (BMD) in children and whether bone-specific alkaline phosphatase (B-ALP), and insulin-like growth factor 1 (IGF-1) mediate the relationship between TCBI and BMD.

methodsThis study included 411 preschool children from 2 township kindergartens in a rural area of Gansu Province, China, who were surveyed at baseline in September 2021 and followed up in September 2022. The independent variable is the mean value of TCBI at baseline and follow-up. The dependent variable was the raw value of BMD during the follow-up period, measured by dual-energy X-ray absorptiometry. Multiple linear regression was used to analyze the relationship between TCBI and BMD in the nondominant forearm and heel bone.

resultsThe results showed that TCBI in preschoolers was significantly and positively correlated with BMD (P < 0.001). In the fully adjusted model, for each unit increase in log-transformed TCBI, the BMD of the nondominant forearm and heel bone increased by 0.042 g/cm

conclusionTCBI is positively correlated with nondominant forearm and heel BMD in preschoolers, and IGF-1 and B-ALP partially mediate the positive association between TCBI and BMD.

Indexed as

Body WeightBone and BonesBone DensityCholesterolTriglyceridesAbsorptiometry, PhotonBody Mass IndexChildChild, PreschoolChinaFemaleHumansInsulin-Like Growth Factor ILongitudinal StudiesMaleMediation AnalysisCholesterolIGF1 protein, humanInsulin-Like Growth Factor ITriglyceridesBone mineral densityMediation effectPreschool childrenTriglycerides-Total Cholesterol-Body Weight Index

Identifiers

PMID40445364

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.