ReviewMolecular biology reports2025
Neuron-derived neurotrophic factor and its biological functions: a review study.
Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Neurotrophic Control of Puberty: From Molecular Signaling to Disorders of Pubertal Timing.Current issues in molecular biology · 2025Review
- Identification of Neurotrophic Factor Related Biomarkers and Mechanistic Insights into Neuropathic Pain via Integrated Bioinformatics Analysis.ACS omega · 2025Article
- The Relationship Between Metacognitive Beliefs and Salivary Cortisol, BDNF, and NDNF Levels: A Cross-Sectional Study.Brain and behavior · 2025Article
- Novel compound heterozygous NDNF variants in congenital hypogonadotropic hypogonadism: insights into genotype-phenotype correlation and infertility.Molecular biology reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurotrophic factors (NTFs) are known for their specific functions in the nervous system. One of the latest factors to be studied is neuron-derived neurotrophic factor (NDNF). NDNF was first introduced as NTF in 2010. However, the NDNF-specific expression and function are somewhat different from other NTFs. The most significant known function of NDNF seems to be its role in facilitating the migration of GnRH neurons. To date, limited studies have been conducted on this gene. Therefore, this study aims to review all the information from previous investigations. Additionally, bioinformatics tools and other databases were used to investigate the functions, interactions, and conservation of NDNF. The functional analysis suggested the involvement of conserved NDNF in various molecular and signaling pathways, such as cGMP-PKG and PI3K-AKT. The association of NDNF variants and defects with other diseases and malignancies, such as cancers, seems to be clear. The present study presents all available information on NDNF. Further research is necessary to enhance our knowledge of NDNF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.