Evidence map›Paper›PMID 40445144›Full record

ArticleThe Journal of asthma : official journal of the Association for the Care of Asthma2025

Management of asthma exacerbations in pediatric emergency departments across the United States.

Melisa S Tanverdi, Isabella Zaniletti, Nidhya Navanandan, Isabel Hardee, Andrew H Liu, Rakesh D Mistry

Abstract readMulticenter Study
In one paragraph

Article in The Journal of asthma : official journal of the Association for the Care of Asthma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Melisa S TanverdiDepartment of Pediatrics, Section of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0002-3503-8207
Isabella ZanilettiChildren's Hospital Association, Lenexa, KS, USA.
Nidhya NavanandanDepartment of Pediatrics, Section of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO, USA.ORCID 0000-0002-5058-058X
Isabel HardeeDepartment of Pediatrics, Division of Emergency Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Andrew H LiuDepartment of Pediatrics, Section of Pulmonary and Sleep Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Rakesh D MistryDepartment of Pediatrics, Section of Emergency Medicine, Yale University School of Medicine, New Haven, CT, USA.

Funding

Novel Markers of Treatment Responsiveness for Pediatric Acute Asthma ExacerbationsK23HL161354 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Nidhya Navanandan · 2022 to 2026
$976k
NHLBI NIH HHS K23 HL161354
6 · The paper itself

Abstract

objectivesThere are 750,000 emergency department (ED) visits by children for asthma exacerbations in the United States annually. Despite changing evidence and epidemiology, there have not been recent assessments of acute asthma prevalence, management, and outcomes from pediatric EDs. This 40-center retrospective evaluation utilizes the Pediatric Hospital Information System to characterize pediatric ED asthma presentations from 2015-2020. STUDY

designChildren 2-18 years with asthma ICD-9/10 code and receipt of albuterol were included. Demographics, Child Opportunity Index (COI), ED management, return visits, and adjusted costs were evaluated. Data were summarized using standard descriptive statistics and trends assessed using Mann-Kendall trend test.

resultsThere were 414,264 encounters made by 256,209 unique patients; 21% had >1 visit in 12 months. Median age was 6 years, 61.6% male, 44.5% Black, and 68.5% publicly insured; 58.3% of visits were by patients with very low/low COI. Systemic corticosteroids were administered in 86.3% of visits; 52.7% used dexamethasone. Chest radiographs were obtained in 23% of encounters. Most (74.9%) encounters resulted in ED discharge with a downward trend of visits for exacerbations per 1,000 ED visits of -9.77, 95% CI [-9.99,-9.54], increase in disposition to intensive care unit of 2.01 [1.87,2.41] and decrease in home/other of -3.77 [-4.34,-3.20]. There was no significant trend in return visits. Total adjusted costs were ∼$900 million.

conclusionsED visits for asthma remain frequent and disproportionately affect children with lower social determinants of health. Dexamethasone has not been widely adopted as corticosteroid of choice and use of ancillary testing continues, highlighting opportunities for improvement in asthma care.

Indexed as

AsthmaEmergency Service, HospitalAdolescentAdrenal Cortex HormonesAlbuterolChildChild, PreschoolDexamethasoneFemaleHumansMaleRetrospective StudiesUnited StatesAdrenal Cortex HormonesAlbuterolDexamethasoneChildrendatabasedemographicsdispositionmulticentertestingtreatment

Identifiers

PMID40445144
PMCPMC12236050

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.